PMID: 6969405Nov 1, 1980Paper

Serotonin-mimetic and antidepressant drugs on passive avoidance learning by olfactory bulbectomised rats

Pharmacology, Biochemistry, and Behavior
C L BroekkampK G Lloyd

Abstract

Olfactory bulbectomised rats were treated with drugs and their rate of acquisition of a passive avoidance task was measured. The acquisition-rate, which is disturbed by the bilateral ablations, was completely restored by acute administration of fenfluramine or fluoxetine. Partial restoration was found with quipazine. Clonidine was without effect. Repeated treatments with imipramine and mianserine improved passive avoidance of bulbectomised rats. Metergoline blocked these effects of imipramine and mianserin. These results indicate a serotonergic mechanism in the effect of antidepressants on olfactory bulbectomised rats.

References

Jan 1, 1978·Drugs·F A Whitlock, L E Evans
Jul 1, 1978·Pharmacology, Biochemistry, and Behavior·J L GibbonsS F Leibowitz
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·K D CairncrossH Schnieden
Aug 1, 1977·British Journal of Pharmacology·H van RiezenA F Wren
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M HamonJ Glowinski
Jan 1, 1972·Psychopharmacologia·C Broekkamp, J M van Rossum
May 1, 1973·Journal of Pharmaceutical Sciences·H J BergerJ C Krantz
Mar 1, 1970·European Journal of Pharmacology·I Geller, K Blum
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·D Malec, R Langwinski

❮ Previous
Next ❯

Citations

Jan 1, 1984·Psychopharmacology·P Willner
Jan 1, 1990·Psychopharmacology·P MartinA J Puech
Jan 1, 1987·Psychopharmacology·J F Flood, A Cherkin
Aug 1, 1990·Biological Psychiatry·R MuscatP Willner
Jan 1, 1988·Physiology & Behavior·B M Thorne, J S Rowles
Jul 1, 1996·Physiology & Behavior·M A PrendergastS Balogh
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·D Joly, D J Sanger
May 1, 1993·Pharmacology, Biochemistry, and Behavior·E V GurevichN V Bobkova
Jan 1, 1990·Pharmacology & Therapeutics·H van Riezen, B E Leonard
Jan 1, 1990·Pharmacology & Therapeutics·P Willner
Jun 1, 1996·Brain Research. Cognitive Brain Research·J C Bizot, M H Thiébot
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·A M RedmondB E Leonard
Jul 18, 2002·Behavioural Pharmacology·P Willner, P J Mitchell
Nov 17, 1993·Annals of the New York Academy of Sciences·B M Thorne
Jan 19, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michihiko Iijima, Shigeyuki Chaki
Apr 30, 2005·Biological Psychiatry·Hiske M van der SteltHerman G M Westenberg
Sep 1, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Santiago MonleónAndrés Parra
Jan 1, 1984·Scandinavian Journal of Psychology·T ArcherS B Ross
Jul 18, 2006·Pharmacology, Biochemistry, and Behavior·Robert McArthur, Franco Borsini
Oct 21, 2017·Expert Opinion on Drug Safety·Nicholas T Bello, Bryn L Yeomans
Oct 3, 1999·Journal of Clinical Psychopharmacology·P Popik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.