Serotonin modulates voltage-dependent calcium current in Necturus taste cells

Journal of Neurophysiology
R J DelayS D Roper

Abstract

Necturus taste buds contain two primary cell types: taste receptor cells and basal cells. Merkel-like basal cells are a subset of basal cells that form chemical synapses with taste receptor cells and with innervating nerve fibers. Although Merkel-like basal cells cannot interact directly with taste stimuli, recent studies have shown that Merkel-like basal cells contain serotonin (5-HT), which may be released onto taste receptor cells in response to taste stimulation. With the use of whole cell voltage clamp, we examined whether focal applications of 5-HT to isolated taste receptor cells affected voltage-activated calcium current (I(Ca)). Two different effects were observed. 5-HT at 100 microM increased I(Ca) in 33% of taste receptor cells, whereas it decreased I(Ca) in 67%. Both responses used a 5-HT receptor subtype with a pharmacological profile similar to that of the 5-HT1A receptor, but the potentiation and inhibition of I(Ca) by 5-HT were mediated by two different second-messenger cascades. The results indicate that functional subtypes of taste receptor cells, earlier defined only by their sensitivity to taste stimuli, may also be defined by their response to the neurotransmitter 5-HT and suggest that 5-HT released by Merk...Continue Reading

References

Aug 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·J R RaymondJ P Middleton
Apr 1, 1992·Trends in Pharmacological Sciences·J BockaertD E Clarke
Jan 1, 1991·Journal of Receptor Research·D Hoyer, P Schoeffter
May 1, 1991·Archives of Otolaryngology--head & Neck Surgery·D A DeemsJ B Snow
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·A FrazerB B Wolfe
Dec 1, 1990·Brain Research Bulletin·D H SchwartzB G Hoebel
Feb 1, 1987·The Journal of Physiology·S C Kinnamon, S D Roper
Mar 1, 1989·The Journal of Physiology·G S Oxford, P K Wagoner
Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R MarksteinG Engel
Jan 1, 1986·Psychopharmacology·A M Montgomery, M J Burton
Nov 8, 1988·The Journal of Comparative Neurology·R J Delay, S D Roper
Jan 1, 1987·Journal of Medicinal Chemistry·R A Glennon
Jul 22, 1987·The Journal of Comparative Neurology·T A CummingsS D Roper
Jul 1, 1971·The American Journal of Anatomy·A I Farbman, J D Yonkers
Nov 30, 1984·Biochemical and Biophysical Research Communications·S Kawamoto, H Hidaka
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Mar 13, 1995·The Journal of Comparative Neurology·D J Kim, S D Roper
Nov 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R I Henkin
Aug 22, 1994·The Journal of Comparative Neurology·M McPheetersJ C Kinnamon
Mar 1, 1994·Neuropharmacology·F G Boess, I L Martin
Sep 22, 1993·The Journal of Comparative Neurology·R J DelayS D Roper
Jun 1, 1993·Trends in Pharmacological Sciences·P P HumphreyD Hoyer
May 28, 1993·Biochemical and Biophysical Research Communications·M RuatJ C Schwartz
Jul 1, 1993·The Journal of General Physiology·A Bigiani, S D Roper
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M RuatJ C Schwartz

❮ Previous
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Citations

Sep 25, 2002·The European Journal of Neuroscience·Kotapola G ImendraKazuo Toda
Jul 25, 2003·Journal of Neurophysiology·Sergey G BaryshnikovStanislav S Kolesnikov
Sep 20, 2007·The Journal of Comparative Neurology·Gennady DvoryanchikovNirupa Chaudhari
Apr 1, 1999·Annual Review of Physiology·M S Herness, T A Gilbertson
Mar 25, 2008·The Bulletin of Tokyo Dental College·Takashi Suzuki
May 1, 2007·Pflügers Archiv : European journal of physiology·Stephen D Roper
Aug 9, 2013·Journal of Psychopharmacology·Shrikant SrivastavaJohn Potokar
Jun 22, 2019·Zoological Letters·Tatsuya ItoyamaYasunori Murakami
Apr 1, 1999·The Journal of Comparative Neurology·K ToyoshimaS Takeda
Jun 12, 1998·Japanese Journal of Pharmacology·T YamamotoY Yasoshima
Sep 15, 2001·Nature·B Lindemann
Jan 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Namik KayaScott Herness
Sep 21, 2000·The European Journal of Neuroscience·D M LawtonC M Hackney
Mar 29, 2000·The Journal of Nutrition·J G Brand
Apr 12, 2002·Progress in Neurobiology·Albertino Bigiani
Nov 7, 2007·Cell Metabolism·Laurence H Tecott
Apr 12, 2011·Acta histochemica·Peter C Zachar, Michael G Jonz

❮ Previous
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