Serotonin nerve terminals in adult rat neocortex.

Brain Research
L DescarriesK C Watkins

Abstract

Axonal processes which take up and retain exogenous tritiated serotonin ([3H]5-HT) have been demonstrated in the fronto-parietal cortex of adult rats, by means of high resolution radioautography. Prolonged topical superfusion with relatively high concentrations of ([3H]5-HT allowed detection of a maximal number of axonal reactions in the upper 3 layers of cortex. Comparison of results obtained from normal rats and animals pretreated with 6-hydroxydopamine or bearing midbrain raphe lesions established the specificity of this labeling. All reactive axons seemed to arise from the serotonin nerve cell bodies in groups B7 and B8 of Dahlström and Fuxe15. In electron microscope radioautographs, the serotonin fibers appeared as tenuous, naked axonal processes (0.1-0.5 mum in diameter) exhibiting small enlargements (0.7 mum in mean diameter) spaced at frequent intervals (1-3 mum). These boutons contained occasional mitochondria, small, round, agranular 'synaptic' vesicles and large granular vesicles. With axons, [3H]5-HT was concentrated in the boutons, and to a much lesser extent in connecting segments. This reactive pattern resembled that revealed by the fluorescence technique for endogenous serotonin. Preferential accumulations of th...Continue Reading

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Citations

Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries
May 1, 1990·Journal of Electron Microscopy Technique·B E MaleyR P Elde
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