Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaques.

Development and Psychopathology
Erin L KinnallyJohn P Capitanio

Abstract

A subset of serotonin (5-HT) pathway polymorphisms has been shown to confer risk for psychological dysfunction, particularly in individuals who experience early adversity. Understanding the developmental processes underlying these Gene x Environment interactions will strengthen the search for risk factors for behavioral dysfunction. We investigated the combined influence of two serotonin pathway polymorphisms and species-atypical, and possibly adverse, rearing (nursery rearing [NR]) on two dimensions of behavioral stress response in infant rhesus macaques. We hypothesized that the experience of NR and possession of both "high-risk" genotypes (genotypes that are thought to confer low 5-HT function) would predict the greatest behavioral stress response to maternal/social separation. Using a matched-pair design, the impact of early experience and the serotonin transporter (rh5-HTTLPR) and monoamine oxidase A (rhMAO-A-LPR) promoter polymorphisms on behavioral reactivity of 136 infant rhesus macaques (90-120 days of age) during a 25-hr social separation/relocation procedure was assessed. Each pair included one infant reared with mother in a large, outdoor field enclosure (field rearing) and one infant reared in a nursery (NR). Pairs...Continue Reading

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Oct 14, 2011·Journal of Applied Genetics·Konstantin A PavlovVladimir P Chekhonin
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Apr 16, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth K WoodJ Dee Higley

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