Serotonin promotes tumor growth in human hepatocellular cancer

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Christopher SollPierre-Alain Clavien

Abstract

In addition to its function as a neurotransmitter and vascular active molecule, serotonin is also a mitogen for hepatocytes and promotes liver regeneration. A possible role in hepatocellular cancer has not yet been investigated. Human hepatocellular cancer cell lines Huh7 and HepG2 were used to assess the function of serotonin in these cell lines. Characteristics of autophagy were detected with transmission electron microscopy, immunoblots of microtubule-associated protein light chain 3(LC3) and p62 (sequestosome 1). Immunoblots of the mammalian target of rapamycin (mTOR) and its downstream targets p70S6K and 4E-BP1 were used to investigate signaling pathways of serotonin. Two different animal models served as principle of proof of in vitro findings. Clinical relevance of the experimental findings was evaluated with a tissue microarray from 168 patients with hepatocellular carcinoma. Serotonin promotes tumor growth and survival in starved hepatocellular carcinoma cells. During starvation hepatocellular carcinoma cells exhibited characteristics of autophagy, which disappeared in serotonin-treated cells. Rapamycin, an inhibitor of mTOR, is known to induce autophagy. Serotonin could override rapamycin by an mTOR-independent pathwa...Continue Reading

References

Mar 1, 1995·Trends in Pharmacological Sciences·G BaxterT Blackburn
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Balasubramanian, C S Paulose
Mar 28, 2002·Pharmacology & Therapeutics·J R RaymondM N Garnovskaya
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Canan G NebigilLuc Maroteaux
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Oct 26, 2005·Cell Death and Differentiation·G KroemerUNKNOWN Nomenclature Committee on Cell Death
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Apr 8, 2006·Science·Mickael LesurtelPierre-Alain Clavien
Aug 29, 2006·The American Journal of Pathology·Richard G RuddellDerek A Mann
Feb 27, 2007·Journal of Hepatology·David SemelaJean-François Dufour
Sep 6, 2007·Journal of Cellular Physiology·Enrique Rozengurt
Sep 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C ColletM-C de Vernejoul
Nov 2, 2007·Nature Reviews. Cancer·Robin MathewEileen White
Dec 15, 2007·Cellular and Molecular Life Sciences : CMLS·M LesurtelP-A Clavien
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Mar 11, 2008·Lancet·Detlef Schuppan, Nezam H Afdhal
Apr 17, 2008·Nature Reviews. Molecular Cell Biology·Alexei Degterev, Junying Yuan
Jun 3, 2008·Nature Medicine·Philipp A LangKarl S Lang
Jul 3, 2008·Cancer Research·Antonio NocitoPierre-Alain Clavien
Jul 25, 2008·Journal of Cellular Physiology·Catherine Jonnakuty, Claudia Gragnoli
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Oct 24, 2008·International Journal of Cancer. Journal International Du Cancer·Marc-Oliver RienerWolfram Jochum
Feb 10, 2009·Methods in Enzymology·Geir BjørkøyTerje Johansen

❮ Previous
Next ❯

Citations

Mar 2, 2011·Journal of Neural Transmission·Jean C ShihKevin Chen
Sep 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeremy Veenstra-VanderWeele, Randy D Blakely
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Katarzyna FurrerPierre-Alain Clavien
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Giovanni SitiaLuca G Guidotti
Aug 1, 2014·Theoretical Biology & Medical Modelling·Joanna ZylaJoanna Polanska
Jul 16, 2014·Seminars in Oncology·Brian I CarrUNKNOWN Italian Liver Cancer (ITA.LI.CA) group
May 29, 2014·The Journal of Clinical Investigation·Jason Boyang WuLeland W K Chung
Jan 15, 2013·Digestive Diseases and Sciences·Brian I Carr, Vito Guerra
Jun 14, 2015·FEBS Letters·Rabih El-MerahbiGrzegorz Sumara
Feb 20, 2015·Hämostaseologie·M MaulerD Duerschmied
Jul 8, 2014·Blood Cells, Molecules & Diseases·Vera GaunPaula G Fraenkel
Oct 18, 2015·Molecular Oncology·Sarwat FatimaZhao Xiang Bian
Nov 29, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M LesurtelP-A Clavien
Aug 23, 2011·International Journal of Pharmaceutics·Vijaya GopalN Madhusudhana Rao
Oct 27, 2015·Medicine·Hsiang-Lin ChanVincent Chin-Hung Chen
Oct 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing PangXin Sen Xu
Dec 7, 2014·The Journal of Physiology·Adriano GuetgFrançois Verrey
Jan 8, 2016·European Journal of Gastroenterology & Hepatology·Ahmed Abdel-RazikAhmed Tawfik
Jun 8, 2013·Journal of Hepatology·Giovanni SitiaLuca G Guidotti
Aug 4, 2015·Clinical & Experimental Metastasis·Jae-Hwi JangWolfgang Jungraithmayr
Jun 5, 2014·International Journal of Cancer. Journal International Du Cancer·Chaofu KeKang Li
Dec 30, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Paul DowlingMartin Clynes
Jan 25, 2012·Immunopharmacology and Immunotoxicology·Markus RitterKlas Nordlind
Dec 1, 2014·BMC Gastroenterology·Konstantinos N TzirogiannisGeorgios I Panoutsopoulos
Mar 9, 2012·Neuromuscular Disorders : NMD·Luigi Michele PavoneOrlando Paciello
Oct 19, 2010·Journal of Hepatology·Christopher Soll, Pierre-Alain Clavien
Oct 2, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Marloes A M PetersSjoukje F Oosting
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N M Abdel-HamidAhmed Wahid
Jul 28, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Chhagan BihariShiv K Sarin
Oct 27, 2016·Pharmacology & Therapeutics·Luc MaroteauxLaurent Monassier
Jul 19, 2013·European Journal of Gastroenterology & Hepatology·Brian I Carr, Vito Guerra
Jan 30, 2015·Scientific Reports·Jingyao ZhangChang Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms