Serotonin receptor modulators in the treatment of irritable bowel syndrome.

Therapeutics and Clinical Risk Management
Mohammad Fayyaz, Jeffrey M Lackner

Abstract

The aim of this article is to review the pathophysiology and clinical role of serotonin receptor modulators used in the treatment of irritable bowel syndrome. Serotonin is an important monoamine neurotransmitter that plays a key role in the initiation of peristaltic and secretory refl exes, and in modulation of visceral sensations. Several serotonin receptor subtypes have been characterized, of which 5HT3, 5HT4, and 5HT1b are the most important for GI function. 5HT4 agonists (eg, tegaserod) potentiate peristalsis initiated by 5HT1 receptor stimulation. 5HT4 agonists are therefore useful in constipation predominant form of IBS and in chronic constipation. 5HT3 antagonists (Alosetron and Cilansetron) prevent the activation of 5HT3 receptors on extrinsic afferent neurons and can decrease the visceral pain associated with IBS. These agents also retard small intestinal and colonic transit, and are therefore useful in diarrhea-predominant IBS. Tegaserod has been demonstrated in several randomized, placebo controlled trials to relieve global IBS symptoms as well as individual symptoms of abdominal discomfort, number of bowel movements and stool consistency. Several randomized, controlled trials have shown that alosetron relieves pain,...Continue Reading

Citations

Nov 7, 2019·Probiotics and Antimicrobial Proteins·Yen-Wenn LiuYing-Chieh Tsai
Jan 16, 2010·Journal of Gastroenterology and Hepatology·Oliver Grundmann, Saunjoo L Yoon
Nov 1, 2017·Digestive Diseases and Sciences·Martina Führer, Johann Hammer
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Hye-Kyung Jung
Jan 10, 2017·Frontiers in Neuroscience·Andromeda Linan-RicoFievos L Christofi
Nov 13, 2019·The Journal of Physiology·Clarissa M D Mota
Sep 26, 2020·Frontiers in Immunology·Thomas Wesley HodoAnil Shanker
Dec 16, 2018·International Journal of Molecular Sciences·Mirim Jin, Miwon Son
May 28, 2021·World Journal of Gastroenterology : WJG·Byungchang JinSeungil Ro
Mar 2, 2011·Pharmacology & Therapeutics·Tina K Machu
Mar 16, 2011·Neuroscience and Biobehavioral Reviews·Dave J Hayes, Andrew J Greenshaw

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