PMID: 11319770Apr 25, 2001Paper

Serotonin regulation of nerve growth factor synthesis in neonatal and adult astrocytes: comparison to the beta-adrenergic agonist isoproterenol

Journal of Neuroscience Research
M KrzanJ P Schwartz

Abstract

Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content in neonatal astrocytes but not in adult astrocytes. In neonatal striatal astrocytes, serotonin increases both cAMP and NGF, whereas, in neonatal cerebellar astrocytes, serotonin decreases both. The increase in neonatal cortical astrocyte cAMP appeared to be too small (45%) to increase NGF significantly. The beta-adrenergic agonist isoproterenol increased cAMP and NGF in both cortical and striatal astrocytes derived from neonatal rats. In contrast, there was a dissociation between cAMP changes and NGF changes in astrocytes derived from adult rats. Both serotonin and isoproterenol increased cAMP in adult cortical astrocytes, without any effect on NGF content. However, adult striatal astrocytes responded to serotonin with an elevation of both cAMP and NGF, whereas isoproterenol could only enhance cAMP, without affecting NGF. Thus, in neonatal astrocytes, a change of sufficient magnitude in cAMP was correlated with a co...Continue Reading

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Citations

Nov 14, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M Juric, M Carman-Krzan
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carolina IsiegasTed Abel
May 14, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Spela MiklicMarija Caman-Krzan
Oct 27, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tina MeleDamijana Mojca Juric
Sep 25, 2002·The European Journal of Neuroscience·Mauro VairanoPierluigi Navarra
Feb 15, 2019·International Journal of Molecular Sciences·Zhiwen ZhouRyuta Koyama

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