Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer's Disease Patients with Depressive Symptoms

Journal of Alzheimer's Disease : JAD
Matthias BrendelAlzheimer’s Disease Neuroimaging Initiative

Abstract

Late-life depression, even when of subsyndromal severity, has shown strong associations with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we aimed to investigate the effect of SSRI medication on amyloidosis and grey matter volume in subsyndromal depressed subjects with MCI and AD during an interval of two years. 256 cognitively affected subjects (225 MCI/ 31 AD) undergoing [18F]-AV45-PET and MRI at baseline and 2-year follow-up were selected from the ADNI database. Subjects with a positive depression item (DEP(+); n = 73) in the Neuropsychiatric Inventory Questionnaire were subdivided to those receiving SSRI medication (SSRI(+); n = 24) and those without SSRI treatment (SSRI(-); n = 49). Longitudinal cognition (Δ-ADAS), amyloid deposition rate (standardized uptake value, using white matter as reference region (SUVRWM), and changes in grey matter volume were compared using common covariates. Analyses were performed separately in all subjects and in the subgroup of amyloid-positive subjects. Cognitive performance in DEP(+)/SSRI(+) subjects (Δ-ADAS: -5.0%) showed less deterioration with...Continue Reading

References

Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Sep 23, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·D I KauferS T DeKosky
May 3, 2006·Archives of General Psychiatry·Raymond L OwnbyDavid Loewenstein
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael W Weiner
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Lisa MosconiMony J de Leon
Aug 11, 2011·Human Brain Mapping·Dominic HollandUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·John R CirritoYvette I Sheline
Sep 6, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shinichiro NakajimaMasaru Mimura
Oct 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming-Ying DuQi-Yong Gong
Oct 28, 2011·Journal of Affective Disorders·Lisa C BarryThomas M Gill
Nov 22, 2011·Acta Neuropathologica·Elliott J MufsonStephen W Scheff
Dec 23, 2011·Parkinsonism & Related Disorders·Feng ZhangHui-Ming Gao
Feb 11, 2012·Biological Psychiatry·Grace J LeeUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 2, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuki NamekawaHeii Arai
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·R Scott MackinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Jan 15, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Aleksandra LebedevaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 8, 2014·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Christine Leong
May 16, 2014·Science Translational Medicine·Yvette I ShelineJohn R Cirrito
Nov 18, 2014·Frontiers in Neuroscience·Paul A AdlardGary F Egan
Nov 22, 2014·The Australian and New Zealand Journal of Psychiatry·Karra D HarringtonPaul Maruff
Dec 9, 2014·NeuroImage·Matthias BrendelUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 30, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Matthias BrendelUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 4, 2015·Translational Neurodegeneration·Wen-Ying WangLan Tan
May 20, 2015·JAMA : the Journal of the American Medical Association·Rik OssenkoppeleDavid J Brooks
Jun 16, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 25, 2015·Journal of Geriatric Psychiatry and Neurology·Jun Ku ChungUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 2, 2016·Ageing Research Reviews·Victor L Villemagne, Gaël Chételat
Mar 15, 2016·Current Alzheimer Research·Matthias Brendel Alzheimer's Disease Neuroimaging Initiative
Mar 18, 2016·ACS Chemical Neuroscience·Daniel S AlbrechtMarco L Loggia
Mar 31, 2016·Current Alzheimer Research·Marcus Högenauer Alzheimer's Disease Neuroimaging Initiative
Apr 27, 2016·International Journal of Geriatric Psychiatry·Karra D HarringtonUNKNOWN AIBL Research Group

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Citations

Jul 30, 2018·Journal of Alzheimer's Disease : JAD·Juan Manuel GórrizJavier Ramirez
May 15, 2020·Current Topics in Medicinal Chemistry·Friedrich LeblhuberJohanna M Gostner
Sep 20, 2019·Neural Regeneration Research·Bernadette MdawarRita Khoury

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