PMID: 7514199May 1, 1994Paper

Serotonin-stimulated aortic endothelial cells secrete a novel T lymphocyte chemotactic and growth factor

Journal of Leukocyte Biology
M F KatzD J Beer

Abstract

Atherosclerotic lesions contain multiple cell types including smooth muscle cells, macrophages, and T lymphocytes. The development of an extralymphatic T lymphocyte focus of inflammation in this condition requires chemoattractant-induced cell migration and growth factor-induced cell activation. In a previous study, we described a novel 13-15-kDa T lymphocyte-specific chemotactic cytokine, endothelial cell-derived lymphocyte chemoattractant activity (ED-LCA), secreted by serotonin-stimulated bovine aortic endothelial cells that is distinct from previously identified endothelial cell-derived interleukins (IL) 1, 6, and 8. Because of the association between T lymphocyte chemotactic and growth factor activity, in the current study we investigated the effect of ED-LCA on T cell growth. We assessed its capacity to induce markers of the passage of T cells from the resting (G0) state into the G1 phase of the cell cycle, such as receptors for IL-2 (IL-2R) and transferrin (TFR) and class II major histocompatibility complex antigens (HLA-DR). Incubation of G0 freshly isolated human T lymphocytes for 48 h with chromatographically resolved, partially purified ED-LCA resulted in a threefold increase in expression of the p55 subunit of IL-2R,...Continue Reading

Citations

Jan 21, 2014·Cardiology in Review·Georgios ChristodoulidisConstantine E Kosmas
Aug 5, 2006·Vascular Medicine·L NorgrenUNKNOWN European MCI-9042 Study Group
Jun 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kimberly A KellyRalph Weissleder
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuaki KokubuKazuaki Shimamoto
Aug 5, 2017·Frontiers in Cardiovascular Medicine·Nadine HerrDaniel Duerschmied

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