PMID: 9535102Apr 16, 1998Paper

Serotonin stimulates corticotropin-releasing factor gene expression in the hypothalamic paraventricular nucleus of conscious rats

Neuroscience Letters
K KageyamaT Suda

Abstract

To examine the direct effects of serotonin (5-HT) on the release and synthesis of corticotropin-releasing factor (CRF) in the hypothalamic paraventricular nucleus (PVN), 5-HT was microinjected just onto the bilateral PVN of conscious rats. Plasma adrenocorticotropic hormone (ACTH) levels peaked at 30 min and returned to the basal levels in 90 min. Northern blot analysis revealed that the CRF messenger RNA (mRNA) level in the PVN as well as the proopiomelanocortin mRNA level in the anterior pituitary significantly increased 120 min after the 5-HT injections (50-250 nmol/side). Pretreatment with intracerebroventricular (i.c.v.) injection of pindobind 5-HT1A (5 nmol) or LY-278584 (500 nmol) completely abolished the 5-HT-induced ACTH response, whereas LY-53857 (100 nmol) was without effect. These results suggest that 5-HT stimulates CRF release, which has interactions with 5-HT1A and 5-HT3 receptors on CRF neurons in the PVN, and activates CRF synthesis in conscious rats.

References

Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Z Baram, S P Lerner
Jan 1, 1987·Annals of the New York Academy of Sciences·A Negro-VilarF Lopez

❮ Previous
Next ❯

Citations

Jul 4, 2002·Current Pain and Headache Reports·Gail K AdlerKatharine W Creskoff
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·Stephen G Matthews
Mar 10, 2000·Pediatric Research·S G Matthews
Apr 1, 2008·Biomarkers in Medicine·James J H Rucker, Peter McGuffin
Dec 24, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Lea R MedeirosM Danielle McDonald
Oct 24, 2007·Pharmacology & Therapeutics·John D Fernstrom, Sujean Choi
Jul 9, 2004·Annals of the New York Academy of Sciences·J RiojaJ A Aguirre
Jun 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yayoi SaegusaHiroshi Takeda
Apr 14, 2010·The Psychiatric Clinics of North America·Lesley M Arnold
Apr 7, 2009·Regulatory Peptides·Jan A MennigenVance L Trudeau
Dec 11, 2007·Behavioural Brain Research·Małgorzata LehnerAdam Płaźnik
Jun 30, 2011·American Journal of Physiology. Endocrinology and Metabolism·Yayoi SaegusaMasahiro Asaka
Jun 6, 2020·Frontiers in Behavioral Neuroscience·Xiaoqiang SunShuqiao Yao
Nov 23, 2017·Frontiers in Neuroscience·Yuki HiguchiIshwar S Parhar
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T W Bailey, J A Dimicco
Nov 14, 2008·Stress : the International Journal on the Biology of Stress·Karen L SmithDavid P Finn
Jul 12, 2021·BMC Research Notes·Eva Hydbring-SandbergOdd Viking Höglund

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.