Serotonin, the periaqueductal gray and panic

Neuroscience and Biobehavioral Reviews
Frederico G Graeff

Abstract

This article reviews experimental evidence and theoretical constructs that implicate serotonin (5-HT) modulation of defensive behavior within the midbrain periaqueductal gray in panic disorder (PD). Evidence with conflict tests in experimental animals indicates that 5-HT enhances anxiety, whereas results with aversive stimulation of the dorsal periaqueductal gray point to an anxiolytic role of 5-HT. To solve this contradiction, it has been suggested that the emotional states determined by the two types of animal model are different. Conflict tests would generate conditioned anxiety, whereas periaqueductal gray stimulation would produce unconditioned fear, as evoked by proximal threat. Clinically, the former would be related to generalized anxiety while the latter to PD. Thus, 5-HT is supposed to facilitate anxiety, but to inhibit panic. This hypothesis has been tested in the animal model of anxiety and panic named the elevated T-maze, in two procedures of human experimental anxiety applied to healthy volunteers or panic patients, and in CO2-induced panic attacks. Overall, the obtained results have shown that drugs that enhance 5-HT function increase different indexes of anxiety, but decrease indexes of panic. Drugs that impair ...Continue Reading

References

Jul 1, 1975·Physiology & Behavior·R S Kiser, R M Lebovitz
Jul 1, 1978·Pharmacology, Biochemistry, and Behavior·R S KiserR M Lebovitz
Feb 1, 1977·The British Journal of Social and Clinical Psychology·J Vila, H R Beech
Jan 1, 1991·Psychopharmacology·R HensmanJ F Deakin
Jun 1, 1989·Psychiatry Research·S D Targum, L E Marshall
Jun 1, 1989·Archives of General Psychiatry·E M ReimanK A Hackman
Nov 1, 1986·Behavioural Brain Research·P SchmittG Sandner
Jan 1, 1985·Psychopharmacology·M T SchützF G Graeff
Jan 1, 1987·Acta Psychiatrica Scandinavica. Supplementum·D F Klein, J M Gorman
Apr 1, 1986·The American Journal of Psychiatry·E M ReimanJ Perlmutter
Jan 1, 1985·Psychopharmacology·F G GraeffI G Karniol
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·S Morato de CarvalhoF G Graeff
Jan 1, 1982·Psychopharmacology·D M McNairS Fisher
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·F G Graeff, J N Rawlins
Dec 20, 1993·Behavioural Brain Research·F G GraeffR M Oliveira
Apr 1, 1994·The American Journal of Psychiatry·L Solyom
Oct 1, 1996·Psychopharmacology·L A HetemF G Graeff
Mar 1, 1997·Journal of Anxiety Disorders·G C PhillipsJ B Snell
Jun 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·H Selye
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·F G GraeffH Zangrossi
Oct 13, 1999·The American Journal of Psychiatry·I Z Ben-ZionJ Benjamin
Mar 30, 2000·The American Journal of Psychiatry·J M GormanJ D Coplan
May 24, 2000·Psychopharmacology·C Mortimore, I M Anderson
May 30, 2001·Neuroscience and Biobehavioral Reviews·D C BlanchardR J Blanchard
Aug 11, 2001·Psychopharmacology·M SilvaF G Graeff
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L C SchenbergL C Vargas
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·F G GraeffF S Guimarães
Apr 13, 2002·Journal of Psychopharmacology·Caroline BellDavid J Nutt
Oct 10, 2002·Psychopharmacology·Frederico G Graeff
Nov 9, 2002·Brain Research. Brain Research Reviews·Albert AdellFrancesc Artigas
Apr 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F G GraeffF S Guimarães

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Citations

May 12, 2007·Psychopharmacology·Fábio M CorregiariMárcio Bernik
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
Mar 19, 2013·Behavioural Brain Research·Christiana Villela de Andrade StraussHelio Zangrossi
Jun 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alexandre C B V ParenteFrederico G Graeff
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Y-Lan Boureau, Peter Dayan
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicolas Narboux-NêmeRaymond Mongeau
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giampaolo PernaLaura Bellodi
Jun 21, 2011·Psychiatry and Clinical Neurosciences·Akiko FujiwaraYoshio Hirayasu
Jul 29, 2010·Genes, Brain, and Behavior·S MartinE D Bel
Apr 30, 2009·Annual Review of Neuroscience·Peter Dayan, Quentin J M Huys
Jan 11, 2014·PloS One·Estela Castilla-OrtegaFrancisco Javier Pavón
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kae NakamuraOkihide Hikosaka
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dean MobbsChristopher D Frith
Mar 23, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F G Graeff
Mar 28, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T T MiguelR L Nunes-de-Souza
Oct 16, 2014·Neuroscience and Biobehavioral Reviews·Luiz Carlos SchenbergJeyce Willig Quintino-Dos-Santos
Mar 14, 2009·Neural Plasticity·Cristina Marta Del-Ben, Frederico Guilherme Graeff
Mar 22, 2014·Neurology Research International·Foyet Harquin SimpliceNgatanko Abaissou Hervé Hervé
Jan 6, 2007·Psychopharmacology·Luciana Chrystine OliveiraMarcus Lira Brandão
Mar 26, 2014·Neuroscience and Biobehavioral Reviews·Evan D PaulChristopher A Lowry
Oct 4, 2014·Neuroscience and Biobehavioral Reviews·Cybele Garcia-LealCristina Marta Del-Ben
Dec 3, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P H GobiraD C Aguiar
Jan 30, 2013·Behavioural Brain Research·Muhammed SaifRobert Gerlai
Dec 15, 2015·Neuroscience Letters·Francesco RigoliAndrew Calder

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