Serotonin transduction cascades mediate variable changes in pyloric network cycle frequency in response to the same modulatory challenge.

Journal of Neurophysiology
Nadja SpitzerDeborah J Baro

Abstract

A fundamental question in systems biology addresses the issue of how flexibility is built into modulatory networks such that they can produce context-dependent responses. Here we examine flexibility in the serotonin (5-HT) response system that modulates the cycle frequency (cf) of a rhythmic motor output. We found that depending on the preparation, the same 5-min bath application of 5-HT to the pyloric network of the California spiny lobster, Panulirus interruptus, could produce a significant increase, decrease, or no change in steady-state cf relative to baseline. Interestingly, the mean circuit output was not significantly different among preparations prior to 5-HT application. We developed pharmacological tools to examine the preparation-to-preparation variability in the components of the 5-HT response system. We found that the 5-HT response system consisted of at least three separable components: a 5-HT(2betaPan)-like component mediated a rapid decrease followed by a sustained increase in cf; a 5-HT(1alphaPan)-like component produced a small and usually gradual increase in cf; at least one other component associated with an unknown receptor mediated a sustained decrease in cf. The magnitude of the change in cf produced by e...Continue Reading

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Citations

Oct 14, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Wolfgang Stein
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eve Marder
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Dec 3, 2014·Current Opinion in Neurobiology·Eve MarderAdriane G Otopalik
Aug 1, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francis B ArnaldoGisela P Concepcion
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Aug 28, 2021·International Journal of Molecular Sciences·Audrey J MuscatoPatsy S Dickinson

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