PMID: 11925298Apr 2, 2002Paper

Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study

The American Journal of Psychiatry
T MantereJari Tiihonen

Abstract

Lesions of the medial prefrontal cortex and dysfunctions in serotonin turnover are two well-established factors associated with impulsive and sociopathic behaviors, but no firm neuroanatomical data have linked these pathophysiological findings. The aims of this study were to identify putative areas in the human brain that are rich in serotonin transporter sites, particularly within the medial prefrontal cortex, and to determine whether serotonin transporter density in this area is altered among alcoholic subjects. Serotonin transporter density was measured among 17 alcoholic and 10 nonalcoholic comparison subjects by postmortem whole-hemisphere autoradiography with [(3)H]citalopram. In the human cerebral cortex, serotonin transporter binding sites were concentrated in the perigenual anterior cingulate cortex. Substantially sparser serotonin transporter density (up to 35%) was observed in the perigenual anterior cingulate cortex of alcoholic subjects in relation to nonalcoholic comparison subjects. After adjustment for age and postmortem delay, this finding remained statistically significant. A lower serotonin transporter density among the alcoholic subjects was observed, specifically in the so-called "affect" region, suggesting...Continue Reading

Citations

Feb 24, 2006·Psychopharmacology·Javad Salehi Fadardi, W Miles Cox
Feb 3, 2009·Neuropsychology Review·Lorenzo LeggioRobert M Swift
Oct 26, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José M Oliva, Jorge Manzanares
Nov 26, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Markus StorvikJari Tiihonen
Apr 1, 2007·Indian Journal of Psychiatry·Swapnil Gupta, Parmananda Kulhara
Sep 16, 2014·Drug and Alcohol Dependence·Ansel T HillmerBradley T Christian
Jul 21, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Pei-Shen HoSan-Yuan Huang
Nov 26, 2013·Biological Psychiatry·Brittany A MatthewsJeffrey H Meyer
Jun 15, 2004·Human Brain Mapping·Katarina VarnäsHåkan Hall
Mar 4, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marko LehtonenJames C Callaway
Feb 4, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marko LehtonenJ C Callaway
May 25, 2007·Drug and Alcohol Dependence·Igor I GalynkerEdythe D London
Dec 17, 2005·Synapse·Markus StorvikErkki Tupala
Mar 11, 2008·Behavioral Sciences & the Law·Sabrina WeberFrank Schneider
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Amira K BrownRobert B Innis
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Gordon J HarrisMarlene Oscar-Berman
Jun 29, 2011·Biomedical Chromatography : BMC·Ethan H McIlhennySteven A Barker
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jennifer H BarnettPeter B Jones
Jun 20, 2014·Alcoholism, Clinical and Experimental Research·Helene BachMark D Underwood
Dec 14, 2004·Journal of Psychiatric Research·Frédéric LimosinPhilip Gorwood
Sep 4, 2007·Biochemical Pharmacology·Aviel Goodman
Sep 20, 2006·Neuroscience and Biobehavioral Reviews·David H OverstreetAndrew J Lawrence
May 2, 2006·Life Sciences·Brett C Ginsburg, R J Lamb
Feb 5, 2005·Biological Psychiatry·Kate Dimond FitzgeraldStephan F Taylor
Jul 8, 2015·Molecular Psychiatry·R Cervera-JuanesB Ferguson
Apr 22, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Erkki TupalaJari Tiihonen
Nov 27, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Virpi LaukkanenMarkus Storvik
Oct 29, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Olli KärkkäinenMarkus Storvik

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