Serotonin transporter gene polymorphism modulates inflammatory cytokine responses during acute stress

Scientific Reports
Kaori YamakawaHideki Ohira

Abstract

Cytokines are important mediators of various stress-related modulations of immune function. A major genetic factor determining inter-individual differences in stress reactivity is polymorphisms of the serotonin (5-hydroxytryptamine, 5HT) transporter (5HTT) gene. A short (S) variant, compared with a long (L) variant, of the promoter region of the 5HTT gene-linked polymorphic region (5HTTLPR) has been related to emotional and stress hyper-reactivity. The present study examined whether the 5HTTLPR can modulate responses of inflammatory cytokines under acute stress. Nine Japanese male participants carrying two copies of the S alleles and nine Japanese males carrying S and L alleles underwent the Trier Social Stress Test (TSST). Inflammatory cytokines, endocrine parameters, heart rate and subjective stress were measured before, during and after the task. The participants carrying the SS alleles, but not those carrying the SL alleles, showed a significant increase of IL-1β immediately after TSST. This hyper-reactivity to acute stress in individuals with the SS alleles was also observed in their heart rate and cortisol levels. These results suggest that the S allele of the 5HTTLPR is consistently associated with stress reactivity in m...Continue Reading

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Citations

Feb 6, 2019·Psychopharmacology·Eric C Shattuck
Jun 12, 2020·International Journal of Molecular Sciences·Tuan L A PhamKaeko Kamei
Nov 20, 2018·Acta Tropica·Ana Caroline Melo Dos SantosElaine Virgínia Martins de Souza Figueiredo

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