Serotonin Transporter Gene (SLC6A4) Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants

Child Development
Rosario MontirossoRenato Borgatti

Abstract

Preterm birth and Neonatal Intensive Care Unit (NICU) stay are early adverse stressful experiences, which may result in an altered temperamental profile. The serotonin transporter gene (SLC6A4), which has been linked to infant temperament, is susceptible to epigenetic regulation associated with early stressful experience. This study examined a moderation model in which the exposure to NICU-related stress and SLC6A4 methylation moderated infant temperament at 3 months of age. SLC6A4 methylation at 20 CpG sites was quantified in preterm infants (N = 48) and full-term infants (N = 30) from Italian middle-class families. Results suggested that in preterm infants NICU-related stress might be associated with alterations of serotonergic tone as a consequence of SLC6A4 methylation, which in turn, might associate with temperamental difficulties assessed at 3 months of age.

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Citations

Jan 30, 2016·Child Development·Barry M LesterCarmen Marsit
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Livio ProvenziRosario Montirosso
Dec 13, 2017·Development and Psychopathology·Maria A Gartstein, Michael K Skinner
Aug 3, 2018·Development and Psychopathology·Elisabeth ConradtBruce Ellis
Sep 15, 2020·The Clinical Neuropsychologist·Aryanne de SilvaH Gerry Taylor
Oct 12, 2017·Frontiers in Psychology·Livio ProvenziRosario Montirosso
Oct 31, 2017·Child Development Perspectives·Elisabeth Conradt
Dec 12, 2018·Frontiers in Behavioral Neuroscience·Livio ProvenziRosario Montirosso
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Jan 26, 2021·Frontiers in Psychiatry·Femke LammertinkManon J N L Benders
Feb 23, 2021·Infant Behavior & Development·Carolina Beatriz Savegnago MartinsMaria Beatriz Martins Linhares
Oct 8, 2020·Psychoneuroendocrinology·Eva Hucklenbruch-RotherKatrin Mehler
Jun 4, 2021·Frontiers in Psychology·Isabella Lucia Chiara Mariani WigleyRosario Montirosso
Sep 15, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Georgia ChalfunMaria Clara de Magalhães-Barbosa

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