Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion.

NeuroImage
Allison C NugentWayne C Drevets

Abstract

Acute tryptophan depletion (ATD) putatively results in a transient reduction in central serotonin transmission, and induces depressed mood in some un-medicated subjects with remitted major depressive disorder (MDD). The 5-HT transporter promoter region length polymorphism (5-HTTLPR) has been shown to influence behavioral and metabolic responses to ATD, as well as the risk for developing MDD within the context of stress. The current study investigates the relationships between 5-HTTLPR genotype, neurophysiologic response to ATD, and diagnostic phenotype (healthy control subjects versus MDD subjects differentiated by their depressive response to ATD) using (18)FDG-PET. Un-medicated subjects with remitted MDD and healthy controls were genotyped for the long (l) and short (s) alleles of the 5-HTTLPR polymorphism and categorized into one of three genotypes. On two separate occasions, subjects received either a placebo or an amino acid mixture designed to deplete plasma tryptophan, followed by (18)FDG-PET scanning. Depressive symptoms were rated to determine the diagnostic phenotype. Descriptive and predictive discriminant analyses were performed using brain regional metabolic data to classify according to phenotype and genotype. Ove...Continue Reading

References

Nov 1, 1996·Progress in Neurobiology·Z CohenE Hamel
Mar 29, 1997·Lancet·K A SmithP J Cowen
Apr 24, 1997·Nature·W C DrevetsM E Raichle
Nov 14, 1997·Neuroreport·R LarishH W Mueller-Gaertner
Aug 25, 1999·Biological Psychiatry·F A MorenoP L Delgado
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D F Smith
Feb 23, 2000·Neuroreport·D K KimB J Carroll
Jun 13, 2001·Psychopharmacology·M K SpillmannM Fava
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Wayne C DrevetsMarcus E Raichle
Mar 7, 2002·Archives of General Psychiatry·Dennis S CharneyUNKNOWN Consensus Development Panel
Jun 12, 2002·The International Journal of Neuropsychopharmacology·Pedro L DelgadoAlan J Gelenberg
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Wayne C DrevetsMarcus E Raichle
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siegfried KasperThomas Brücke
Apr 15, 2003·The Journal of Comparative Neurology·Dost OngürJoseph L Price
Jan 22, 2004·European Journal of Human Genetics : EJHG·Julien MendlewiczChristine Van Broeckhoven
Sep 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gwenn S SmithBruce G Pollock
Apr 6, 2005·Archives of General Psychiatry·Matthew S MilakJ John Mann
May 13, 2005·Psychopharmacology·S McKieJ F W Deakin
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Fritz A Henn, Barbara Vollmayr

❮ Previous
Next ❯

Citations

Mar 26, 2011·Neuroscience and Biobehavioral Reviews·Geoffrey van der Plasse, Matthijs G P Feenstra
Jan 3, 2012·Cognitive and Behavioral Practice·Stuart EisendrathMaura McLane
Dec 7, 2010·Psychiatry Research·Allison Carol NugentWayne Curtis Drevets
Oct 10, 2013·Bipolar Disorders·Allison C NugentCarlos A Zarate

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.