Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Lorenzo Leggio, Giovanni Addolorato

Abstract

Cloninger proposed a neurochemical model of alcoholism suggesting that type 2 alcoholics have serotonergic deficits with intact dopaminergic system, whereas the type 1 alcoholics have defected dopaminergic system. The work by Storvik and colleagues recently published on Alcohol and Alcoholism shows some interesting differences on the SERT brain density between the type I and type II alcoholic subtypes. Critically, these findings on different serotonergic role in subtypes of alcohol-dependence revive the concept that alcohol addiction is a heterogeneous disorder associated with varying neurochemical abnormalities. Studies testing serotonergic medications in alcohol-dependent patients classified according to subtypes have shown interesting findings. Accordingly, the identification and standardization of alcoholic subtypes could be useful in guiding research on treatment. New developments in the neurobiological understanding of subtypes of alcoholic patients, could led to get the basis for a more personalized pharmacological therapy.

Citations

Feb 3, 2009·Neuropsychology Review·Lorenzo LeggioRobert M Swift
Nov 26, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Markus StorvikJari Tiihonen
May 20, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Lorenzo Leggio
Apr 22, 2009·Expert Opinion on Investigational Drugs·Giovanni AddoloratoAntonio Gasbarrini
Nov 27, 2008·Alcoholism, Clinical and Experimental Research·George A KennaRobert M Swift
Jan 26, 2012·Alcoholism, Clinical and Experimental Research·Arnt F A SchellekensRobbert-Jan Verkes
Jun 20, 2014·Alcoholism, Clinical and Experimental Research·Helene BachMark D Underwood
Oct 29, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Olli KärkkäinenMarkus Storvik

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