Serotoninergic activation of the basolateral amygdala and modulation of tonic immobility in guinea pig

Brain Research Bulletin
Christie Ramos Andrade Leite-PanissiL Menescal-de-Oliveira

Abstract

Tonic immobility (TI), also known as death feigning or animal hypnosis, is a reversible state of motor inhibition that is not only triggered by postural inversion and/or movement restraining maneuvers but also by repetitive stimulation and pressure on body parts. Evidence has demonstrated that the basolateral nucleus of the amygdala (BLA) is particularly associated with defensive behavior that involves the emotional states of fear and anxiety. In addition, some reports have demonstrated that serotonin (5-HT) released in the amygdala is increased during states of stress and anxiety, principally in the BLA. In the present study, we investigated the effects of serotonergic activation of the BLA on the duration of TI. The results showed that the microinjection of 5-HT (3.0 microg) into the BLA decreased the duration of TI. Similarly, the administration of a 5-HT1A agonist (0.1 microg of 8-hydroxy-dipropylaminotretalin) or 5-HT2 agonist (0.1 microg of alpha-methyl-5-HT) into the BLA reduced the TI duration. The effect of 5-HT2 agonist was reversed by pretreatment with a dose that had no effect per se (0.01 microg) of ketanserin (5-HT2 receptor antagonists) into the BLA. Moreover, the activation of 5-HT1A and 5-HT2 receptors in the B...Continue Reading

References

Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
Sep 1, 1978·Behavioral Biology·D C HattonM E Meyer
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Aug 1, 1986·Journal of Neurosurgery·E G Jones
Aug 13, 1982·European Journal of Pharmacology·J Scheel-Krüger, E N Petersen
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·C W Hennig
Apr 1, 1981·Pharmacology, Biochemistry, and Behavior·L B WallnauP Corso
Oct 1, 1994·Pharmacology, Biochemistry, and Behavior·C FernandesS E File
Jun 1, 1994·Scientific American·J E LeDoux
Dec 20, 1993·Behavioural Brain Research·M DavisM Kim
Sep 30, 1993·Behavioural Brain Research·L Menescal-de-Oliveira, A Hoffmann
Jan 1, 1993·Neuroscience·A J McDonald, J R Augustine
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·S K Sanders, A Shekhar
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·R J BlanchardD C Blanchard
Jan 14, 1998·Neuroreport·L de OliveiraL Menescal-de-Oliveira
Sep 9, 1999·European Journal of Pharmacology·S HashimotoT Koyama
Nov 24, 1999·Brain Research Bulletin·C R MonassiL Menescal-de-Oliveira
Dec 22, 1999·Physiology & Behavior·C RamosL Menescal-De-Oliveira
May 30, 2001·Neuroscience and Biobehavioral Reviews·D C BlanchardR J Blanchard
Jul 18, 2002·Brain Research Bulletin·Christie Ramos Andrade Leite-Panissi, Leda Menescal-de-Oliveira
Aug 31, 2002·Psychopharmacology·Franco BorsiniDonatella Marazziti
Sep 1, 2004·European Journal of Pharmacology·Takeshi InoueTsukasa Koyama
Jan 1, 1991·Neurochemistry International·F RadjaM Hamon

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Citations

Mar 16, 2013·Histochemistry and Cell Biology·Esther AsanKlaus-Peter Lesch
Mar 19, 2013·Behavioural Brain Research·Christiana Villela de Andrade StraussHelio Zangrossi
Jun 23, 2011·Biological Psychology·Eliane VolchanIvan Figueira
Jul 27, 2010·Behavioural Brain Research·Eveline Bis VieiraChristie Ramos Andrade Leite-Panissi
Jan 30, 2010·Neuroscience and Biobehavioral Reviews·Ruben V RialSusana Esteban
Sep 24, 2009·Brain Research Bulletin·Sergio R ZamudioFidel De La Cruz
Apr 3, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Raquel Chacon Ruiz MartinezMarcus Lira Brandão
Nov 28, 2006·Behavioural Brain Research·Carlos Eduardo MacedoMarcus Lira Brandão
Jan 24, 2012·Physiology & Behavior·Mateus Dalbem Ferreira, Leda Menescal-de-Oliveira
Aug 9, 2011·Hormones and Behavior·Vicente Sandoval-HerreraSergio R Zamudio
May 7, 2016·Brain Research·Bruna Balbino de Paula, Christie Ramos Andrade Leite-Panissi
Nov 19, 2015·The International Journal of Neuropsychopharmacology·Morten JensenBirgitte Holst
Jan 10, 2021·Neuroscience and Biobehavioral Reviews·Markus J RantalaIndrikis Krams

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