PMID: 6162002Jan 1, 1980Paper

Serotoninergic development in the postnatal rat brain

Journal of Neural Transmission
T Hedner, P Lundborg

Abstract

Various characteristics of the developing serotoninergic system in the brain of rats aged 1 to 28 days were studied biochemically. The levels of the precursor amino acid tryptophan showed a maximal increase in the blood, brain and cerebrospinal fluid (CSF) during the 7th and 10th postnatal days. The development of tryptophan hydroxlyase activity measured in vivo by means of 5-hydroxytryptophan (5-HTP) accumulation after NSD 1015 was closely related to the 5-hydroxytryptamine (5-HT) levels at the various ages. 5-HTP accumulation and 5-HT levels increased most markedly after the second postnatal week. 5-Hydroxyindoleacetic acid (5-HIAA) levels were found to increase rapidly in the brain but somewhat more slowly in the CSF during the second week of postnatal development. Regional studies of 5-HTP accumulation after NSD 1015, 5-HT and 5-HIAA levels indicated a caudal to rostral way of maturation. The disappearance of 5-HT was measured after inhibition of tryptophan hydroxylase with H 22/54. The half-life generally decreased in the various brain parts with advancing age, and in the younger animals the shortest half-life was found in the most caudal brain parts. At 28 days of age the half-life was similar in all brain parts studied. ...Continue Reading

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Citations

Jan 1, 1984·Journal of Neural Transmission·T HednerP Lundborg
Mar 1, 1990·Brain Research. Developmental Brain Research·M Segal
Mar 1, 1983·Brain Research Bulletin·D P Gilmore, C A Wilson
Nov 1, 1991·Pediatric Neurology·H Yamamoto
Nov 28, 1996·European Journal of Pharmacology·F Molina-HolgadoM L Leret
May 1, 1983·Acta Physiologica Scandinavica·K IversenP Lundborg
Oct 1, 1982·Early Human Development·T HednerP Lundborg
Jan 1, 1985·Journal of Neurochemistry·F ArtigasE Gelpí
Nov 1, 1982·Journal of Neurochemistry·G S SarnaG Curzon
Jan 8, 2018·Metabolic Brain Disease·Kai-Ming DuanHeYa Yu
Jan 1, 1990·European Journal of Nuclear Medicine·A J FischmanH W Strauss
Nov 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A A KhanV Bijlani

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