Serotype- and strain- dependent contribution of the sensor kinase CovS of the CovRS two-component system to Streptococcus pyogenes pathogenesis.

BMC Microbiology
Venelina SugarevaBernd Kreikemeyer

Abstract

The Streptococcus pyogenes (group A streptococci, GAS) two-component signal transduction system CovRS has been described to be important for pathogenesis of this exclusively human bacterial species. If this system acts uniquely in all serotypes is currently unclear. Presence of serotype- or strain-dependent regulatory circuits and polarity is an emerging scheme in Streptococcus pyogenes pathogenesis. Thus, the contribution of the sensor kinase (CovS) of the global regulatory two-component signal transduction system CovRS on pathogenesis of several M serotypes was investigated. CovS mutation uniformly repressed capsule expression and hampered keratinocyte adherence in all tested serotypes. However, a serotype- and even strain-dependent contribution on survival in whole human blood and biofilm formation was noted, respectively. These data provide new information on the action of the CovS sensor kinase and revealed that its activity on capsule expression and keratinocyte adherence is uniform across serotypes, whereas the influence on biofilm formation and blood survival is serotype or even strain dependent. This adds the CovRS system to a growing list of serotype-specific acting regulatory loci in S. pyogenes.

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Citations

Dec 14, 2011·Journal of Bacteriology·Keiji Richard KimuraShigetada Kawabata
Mar 19, 2011·Current Opinion in Infectious Diseases·Nicola N LynskeyShiranee Sriskandan
Feb 27, 2015·Frontiers in Cellular and Infection Microbiology·Tomas FiedlerBernd Kreikemeyer
Oct 5, 2016·JCI Insight·Nikolai SiemensAnna Norrby-Teglund
Sep 17, 2011·Nature Reviews. Microbiology·Jason N ColeMark J Walker
May 6, 2019·The Journal of Microbiology·Anshu BabbarAndreas Itzek
May 16, 2019·Journal of Bacteriology·Artur Matysik, Kimberly A Kline
Apr 6, 2019·Current Drug Targets·Heema K N VyasMartina Sanderson-Smith
Nov 26, 2020·Microorganisms·Puja YadavBarbara Spellerberg
Nov 8, 2020·Antibiotics·Heema K N VyasMartina L Sanderson-Smith
Apr 17, 2021·Scientific Reports·Heema K N VyasMartina L Sanderson-Smith

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Methods Mentioned

BETA
reverse transcription PCR
PCR
Scanning electron microscopy

Software Mentioned

CovRS
BLASTN

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