PMID: 9533725Apr 9, 1998Paper

Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
T J CoffeyB G Spratt

Abstract

Multiply-antibiotic-resistant isolates of serogroup 19 Streptococcus pneumoniae, possessing altered penicillin-binding protein (PBP) 1A, 2B, and 2X genes that are indistinguishable from those of the Spanish multiresistant serogroup 23F clone, are now commonly encountered in Spain. Those isolates that have been serotyped express type 19F capsular polysaccharide. Serotyping of further isolates, and hybridization using a serotype 19F-specific probe, has shown that some of them are serotype 19A, rather than 19F. The Spanish multiresistant serotype 19A, 19F, and 23F multiresistant strains were all shown to be very closely related in overall genotype, as they were indistinguishable by REP-PCR and by the sequencing of internal fragments of three house-keeping genes. The serotype 19A multiresistant strains, like the serotype 19F multiresistant strains, therefore appear to be a serotype variant of the Spanish multiresistant serotype 23F clone, which presumably has arisen by recombination at the capsular locus.

References

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Citations

Nov 30, 2000·Current Infectious Disease Reports·D E LowG D Wright
Mar 6, 1999·Current Opinion in Microbiology·A MorrisD E Low
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen Muñoz-AlmagroRoman Pallares
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Oct 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·L K SiuChih-Chien Wang
Aug 23, 2006·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B SenerO Eser
Dec 4, 2004·Journal of Bacteriology·Angeliki MavroidiBrian G Spratt
Jan 26, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M Ramirez, A Tomasz
May 15, 2015·Journal of Clinical Microbiology·Andries J van TonderAngela B Brueggemann
Oct 14, 2008·Expert Review of Anti-infective Therapy·Michael R Jacobs
Jun 9, 2005·Microbiology·Daniel LlullSaulius Kulakauskas
Sep 2, 2003·Microbiology·Qun LiPeter R Reeves
Jul 20, 2006·Journal of Medical Microbiology·Stuart C Clarke
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antoine Dieudonné-VatranBarbara Albiger
Apr 13, 2019·Microbiology Spectrum·James C Paton, Claudia Trappetti
Dec 2, 2000·Journal of Clinical Microbiology·K OverwegP W Hermans

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