Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa

International Journal of Antimicrobial Agents
Mignon du PlessisGroup for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)

Abstract

A newly described pneumococcal serotype (6C) is indistinguishable from serotype 6A when using the conventional Quellung serotyping method. Serotype 6A isolates were screened by polymerase chain reaction (PCR) for the wciN region of the capsular locus. This study detected serotype 6C among invasive pneumococcal disease (IPD) isolates from national laboratory-based surveillance (2005-2006) in South Africa. No serotype 6C isolates were identified among 23 serotype 6A cases from children enrolled in a 9-valent pneumococcal conjugate vaccine trial (1998-2005). Of 8167 IPD cases reported nationally, viable isolates were available for serotyping in 87% of cases (n=7080). Quellung serotyping identified 608 serotype 6A isolates, of which 606 were further tested for serotype 6C. PCR confirmed serotype 6C in 5% (30/606) of the isolates tested. Serotype 6C isolates were: less likely than 6A to cause disease in children compared with adults (6/30 (20%) vs. 311/550 (57%); P<0.001); more likely to cause laboratory-confirmed meningitis (15/30 (50%) vs. 167/578 (29%); P=0.01); and more likely to demonstrate susceptibility to penicillin (non-susceptibility 0/30 vs. 129/578 (22%); P=0.004). No association with gender, human immunodeficiency virus...Continue Reading

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May 15, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J M MarimonE Pérez-Trallero
Aug 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Catherine McEllistrem, Moon H Nahm
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Dec 17, 2008·Journal of Clinical Microbiology·Sónia NunesHermínia de Lencastre
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Nov 12, 2014·The New England Journal of Medicine·Anne von GottbergUNKNOWN GERMS-SA Investigators
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Jun 2, 2011·The Journal of Antimicrobial Chemotherapy·Dora RoloJosefina Liñares

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