Jul 11, 2006

Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003

Tropical Medicine & International Health : TM & IH
Richard A AdegbolaTumani Corrah

Abstract

To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia. Pneumococcal isolates were obtained from children aged < or =6 years with invasive pneumococcal disease during a Haemophilus influenzae vaccine effectiveness study (1997-2002) and from patients with invasive pneumococcal disease admitted to the MRC hospital, Fajara, for routine care (1996-2003). Isolates were identified, serotyped and tested for antibiotic susceptibility. Five hundred and thirty one pneumococcal isolates were obtained from 518 patients; 55 (10.6%) patients died; 415 isolates (79%) were from blood culture, 84 (16%) from CSF, and 42 (8%) from lung aspirates. Forty serogroups and serotypes were identified; six accounted for 64% and 16 for 86% of all episodes; 33.7% were of serotypes 1 and 5. 23.5% were of a 7-valent vaccine serotype, 57.1% were of a 9-valent vaccine serotype; 56% were of a 7-valent serogroup and 78% were of a 9-valent serogroup. There was a significant increase in the proportion of isolates of non-vaccine serogroup with increasing age (P < 0.0001). Antibiotic resistance had not significantly increased over time; but intermediate non-susceptibility to penicillin had rise...Continue Reading

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  • Citations27

References

Mentioned in this Paper

Meningitis, Haemophilus
Lung
Haemophilus Vaccines
Vaccines, Conjugate
Serotyping
Etiology
Aspirate Substance
Syntomycin
Serogroup
Lung Diseases

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