Serotype distribution of invasive group B streptococcal isolates in Maryland: implications for vaccine formulation. Maryland Emerging Infections Program

The Journal of Infectious Diseases
L H HarrisonA Schuchat

Abstract

Invasive group B streptococcal (GBS) infection is a major health problem among infants and adults. The formulation of GBS vaccines depends on knowledge of the GBS serotype distribution. Serotype V GBS infection appears to have recently emerged, suggesting that the serotype distribution changes over time. GBS isolates from 210 pediatric patients, 23 pregnant women, and 314 nonpregnant adults with invasive infection in Maryland were studied. The predominant serotypes from infants with early-onset disease were as follows: serotype III, 38% of isolates; serotype Ia, 36%; serotype V, 13%; and serotype II, 11%. Although the majority (60%) of isolates among infants with late-onset infection were serotype III, serotype Ia (23%) was also common. The predominant serotype among isolates from nonpregnant adult patients was serotype V, accounting for 29% of the isolates. The serotype distribution differs between pediatric patients and adults and is changing over time. The inclusion of a relatively small number of serotypes in a GBS vaccine could provide protection against the vast majority of isolates.

Citations

Jun 19, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H BergsengK Bergh
Aug 4, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Javier NarváezJaime Vilaseca-Momplet
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Morven S EdwardsCarol J Baker
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Morven S Edwards, Carol J Baker
May 1, 1999·The Pediatric Infectious Disease Journal·M FernandezC J Baker
Sep 24, 1999·The Pediatric Infectious Disease Journal·S KalliolaJ Eskola
Dec 6, 2001·The Pediatric Infectious Disease Journal·H D DaviesUNKNOWN Alberta GBS Study Group
Dec 17, 2004·The Pediatric Infectious Disease Journal·Morven S EdwardsCarol J Baker
Nov 8, 2008·The Pediatric Infectious Disease Journal·Hannah T JordanUNKNOWN Active Bacterial Core Surveillance (ABCs)/Emerging Infections Program Network, CDC
Jul 22, 2011·The Pediatric Infectious Disease Journal·Kirsten FlueggeReinhard Berner
Jan 1, 2008·Interdisciplinary Perspectives on Infectious Diseases·Lixin ZhangBetsy Foxman
Feb 19, 1999·Lancet·A Schuchat
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hervé TettelinClaire M Fraser
Aug 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Herve TettelinClaire M Fraser
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kirsten FlueggeReinhard Berner
Feb 8, 2003·Journal of Clinical Microbiology·Norio OkazakiRobert A Whiley
Mar 22, 2003·Infectious Diseases in Obstetrics and Gynecology·Jennifer M SmithSusan H Jackman
Apr 30, 2003·Archives of Disease in Childhood·C J Baker, M S Edwards
Jun 7, 2003·Journal of Clinical Microbiology·Daniel J DiekemaMichael A Pfaller
Nov 29, 2001·Journal of Clinical Microbiology·I Le Thomas-BoriesE Bingen
Feb 5, 2002·Journal of Clinical Microbiology·Fanrong KongGwendolyn L Gilbert
Jan 5, 2002·Journal of Clinical Microbiology·Fanrong KongGwendolyn L Gilbert
Sep 6, 2003·Journal of Clinical Microbiology·Kim EkelundHelle B Konradsen
Aug 7, 2004·Journal of Clinical Microbiology·John A ElliottHans-Christian Slotved
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Qi ChengVincent A Fischetti
Jan 18, 2005·Clinical Microbiology Reviews·Gunnar LindahlThomas Areschoug
Dec 8, 2005·Journal of Clinical Microbiology·Shannon D ManningThomas S Whittam
Feb 3, 2007·Journal of Clinical Microbiology·Karen M Puopolo, Lawrence C Madoff
Mar 23, 2007·Journal of Clinical Microbiology·Claire PoyartPatrick Trieu-Cuot
May 8, 2007·Emerging Infectious Diseases·Katherine J GrayStephen M Graham

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