Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014

Human Vaccines & Immunotherapeutics
Mehmet CeyhanHakan Uslu

Abstract

Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5 years of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (3...Continue Reading

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Citations

Mar 15, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X ZhouY Liu
Apr 21, 2016·Human Vaccines & Immunotherapeutics·Mehmet CeyhanLyazzat Yeraliyeva
Dec 3, 2016·Human Vaccines & Immunotherapeutics·Sevgen Tanır BasaranogluMehmet Ceyhan
Apr 15, 2017·Expert Review of Vaccines·Robert CohenCorinne Levy
Jun 3, 2017·Human Vaccines & Immunotherapeutics·Ayşe BüyükcamMehmet Ceyhan
Jun 13, 2020·Human Vaccines & Immunotherapeutics·Mehmet CeyhanYasemin Ay Altintop
Jul 28, 2019·Human Vaccines & Immunotherapeutics·B GülhanA Ozkaya-Parlakay

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