PMID: 8969724Dec 1, 1996Paper

Serotype-specific immunoglobulin G antibody responses to pneumococcal polysaccharide vaccine in children with sickle cell anemia: effects of continued penicillin prophylaxis

The Journal of Pediatrics
A B BjornsonC D Reid

Abstract

(1) To determine serotype-specific IgG antibody responses to reimmunization with pneumococcal polysaccharide vaccine at age 5 years in children with sickle cell anemia and (2) to determine whether continued penicillin prophylaxis had any adverse effects on these responses. Children with sickle cell anemia, who had been treated with prophylactic penicillin for at least 2 years before their fifth birthday, were randomly selected at age 5 years to continue penicillin prophylaxis or to receive placebo treatment. These children had been immunized once or twice in early childhood with pneumococcal polysaccharide vaccine and were reimmunized at the time of randomization. Serotype-specific IgG antibody responses to reimmunization varied according to pneumococcal serotype but in general were mediocre or poor; the poorest response was to serotype 6B. The antibody responses were similar in subjects with continued penicillin prophylaxis or placebo treatment, and in subjects who received one or two pneumococcal vaccinations before reimmunization. The occurrence of pneumococcal bacteremia was associated with low IgG antibody concentrations to the infecting serotype. Reimmunization of children with sickle cell anemia who received pneumococcal...Continue Reading

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Citations

Jun 1, 1997·AIDS Patient Care and STDs·R M Rutstein, S E Starr
Jan 10, 2012·British Journal of Haematology·Lori C JordanMichael R DeBaun
Jan 10, 2001·The Journal of Pediatrics·J Knight-Madden, G R Serjeant
Jan 6, 2005·Drugs·Jolanta Bernatoniene, Adam Finn
Oct 11, 2017·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori
Jan 10, 2012·The Pediatric Infectious Disease Journal·Angela M EllisonKim Smith-Whitley
Feb 20, 2004·The Cochrane Database of Systematic Reviews·E G DaviesN Dower
Mar 17, 2021·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori

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