Serotype-Specific Transmission and Waning Immunity of Endemic Foot-and-Mouth Disease Virus in Cameroon

PloS One
L W PomeroyR Garabed

Abstract

Foot-and-mouth disease virus (FMDV) causes morbidity and mortality in a range of animals and threatens local economies by acting as a barrier to international trade. The outbreak in the United Kingdom in 2001 that cost billions to control highlighted the risk that the pathogen poses to agriculture. In response, several mathematical models have been developed to parameterize and predict both transmission dynamics and optimal disease control. However, a lack of understanding of the multi-strain etiology prevents characterization of multi-strain dynamics. Here, we use data from FMDV serology in an endemic setting to probe strain-specific transmission and immunodynamics. Five serotypes of FMDV affect cattle in the Far North Region of Cameroon. We fit both catalytic and reverse catalytic models to serological data to estimate the force of infection and the rate of waning immunity, and to detect periods of sustained transmission. For serotypes SAT2, SAT3, and type A, a model assuming life-long immunity fit better. For serotypes SAT1 and type O, the better-fit model suggests that immunity may wane over time. Our analysis further indicates that type O has the greatest force of infection and the longest duration of immunity. Estimates f...Continue Reading

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Citations

Nov 19, 2015·Transboundary and Emerging Diseases·L W PomeroyR B Garabed
Mar 16, 2018·Transboundary and Emerging Diseases·S K AbdrakhmanovK VanderWaal
Aug 30, 2017·PloS One·Karla I Moreno-TorresRebecca Garabed
Mar 26, 2019·The Journal of Animal Ecology·Cara E BrookAndrew P Dobson
Aug 29, 2019·Proceedings. Biological Sciences·Mallory HarrisErin A Mordecai
Jun 21, 2016·Transboundary and Emerging Diseases·T J D Knight-JonesW Vosloo
Sep 26, 2020·Frontiers in Veterinary Science·Hussaini G UlaramuKris De Clercq

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