PMID: 22584853May 16, 2012Paper

Serous and non-serous ovarian carcinoma: histological tumor type as related to the grade of differentiation and disease prognosis

Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Patrícia Andréia Rodrigues FerreiraSophie Derchain

Abstract

To compare the clinical-pathological features of women with serous and non-serous ovarian tumors and to identify the factors associated with survival. In this reconstructed cohort study, 152 women with ovarian carcinoma, who attended medical consultations between 1993 and 2008 and who were followed-up until 2010 were included. The histological type was clearly established for all women: 81 serous carcinomas and 71 non-serous tumors (17 endometrioid, 44 mucinous and 10 clear cell carcinomas). The crude and adjusted odds ratios (OR), with the respective 95% confidence intervals (95%CI), were calculated for the clinical and pathological features, comparing serous and non-serous histological types. The Hazard Ratios (HR) with 95%CI was calculated for overall survival, considering the clinical and pathological features. Comparison of serous to non-serous tumor types by univariate analysis revealed that serous tumors were more frequently found in postmenopausal women, and were predominantly high histological grade (G2 and G3), advanced stage, with CA125>250 U/mL, and with positive peritoneal cytology. After multivariate regression, the only association remaining was that of high histological grade with serous tumors (adjusted OR 15.1...Continue Reading

Citations

Apr 20, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kun JiangDomenico Coppola

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