PMID: 7544718Jun 1, 1995Paper

Serous effusion cytology in gynecologic malignant mixed müllerian tumors

Diagnostic Cytopathology
J R ModzelewskiJ L Finley

Abstract

We reviewed 51 serous effusions (50 peritoneal/one pleural) from 38 patients with uterine (30 cases) and ovarian (eight cases) malignant mixed Müllerian tumors (MMMT). There were 16 patients (42%) with positive effusion cytology specimens; 13 cases (81%) were diagnosed as adenocarcinoma with three cases (19%) interpreted as having a sarcomatous component. Eight of 16 positive effusion specimens had cell block material available for immunoperoxidase (IP) study that included cytokeratin (AE1/3), vimentin, muscle specific actin (HHF) and S-100 protein to determine if unsuspected mesenchymal components were present in the cases originally diagnosed as carcinoma (six cases), or sarcomas (two cases). In the six cases originally interpreted as carcinoma, three were diagnosed as adenocarcinoma and three as poorly differentiated carcinoma. All three of the cases considered adenocarcinoma and two of those diagnosed as poorly differentiated carcinoma reacted only with AE1/3 and vimentin. The remaining case, considered a poorly differentiated carcinoma, stained only with vimentin. In the two cases having cell blocks interpreted as having a sarcomatous component, only vimentin was positive in one while AE1/3, vimentin, HHF, and S-100 were p...Continue Reading

References

Jan 1, 1992·Diagnostic Cytopathology·P T ValenteP Hanjani
Mar 1, 1991·Human Pathology·F Gorstein, T L Anderson
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S G SilverbergA Miller
Jul 1, 1990·American Journal of Clinical Pathology·P E Swanson
Apr 1, 1989·Gynecologic Oncology·A I KanbourA I Kanbour
Jul 1, 1986·American Journal of Obstetrics and Gynecology·G GeszlerW W Johnston
Jan 1, 1988·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H E AuerbachM J Merino

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Citations

Aug 16, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·T OdaS Tamai

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