Serous Neoplasms of the Pancreas: A Comprehensive Review

Archives of Pathology & Laboratory Medicine
Gregory W Charville, Chia-Sui Kao

Abstract

Serous neoplasms are uncommon, usually cystic tumors that account for less than 1% of all primary pancreatic lesions. They consist predominantly of a monomorphic epithelial cell population with a glycogen-rich, clear cytoplasm, reminiscent of clear cell renal cell carcinoma, with which serous neoplasms share an association with underlying VHL loss-of-function mutations. Serous neoplasms have no metastatic potential. Accurate recognition of this entity, including its various architectural subtypes, is critical to appropriate prognostication and treatment. Immunohistochemical detection of inhibin and calponin expression, along with the absence of both estrogen and progesterone receptors and nuclear β-catenin, can help to distinguish serous neoplasms from mimics. With the advent of minimally invasive and molecularly driven diagnostic techniques, the pathologist's role in the assessment and management of serous neoplasms has become increasingly complex and important. We provide an update on the histologic, immunohistochemical, and molecular features of pancreatic serous neoplasms for the practicing pathologist.

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Citations

Sep 21, 2019·Archives of Pathology & Laboratory Medicine·Amrou AbdelkaderTamara Giorgadze
Nov 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Joseph CarmichealSurinder K Batra
Jun 20, 2021·Current Problems in Surgery·R Matthew WalshBrian K P Goh
Jun 18, 2021·World Journal of Gastroenterology : WJG·Michela VisaniDario de Biase

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