SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma

Oncotarget
Christoph WillmesSelma Ugurel

Abstract

Despite of highly effective new therapeutic strategies, chemotherapy still is an important treatment option in metastatic melanoma. Since predictors of chemotherapy response are rare, drugs and regimens are currently chosen arbitrarily. The present study was aimed at the identification of molecular markers predicting the outcome of chemotherapy in melanoma. Tumor biopsies from metastatic lesions were collected from 203 stage IV melanoma patients prior to chemotherapy onset and used for gene expression profiling (n = 6; marker identification set), quantitative real-time PCR (n = 127; validation set 1), and immunohistochemistry on tissue microarrays (n = 70; validation set 2). The results were correlated to the tumors' in-vitro chemosensitivity and to the patients' in-vivo chemotherapy outcome. SERPINB1 was found to correlate to the in-vitro sensitivity to cisplatin-containing chemotherapy regimens (p = 0.005). High SERPINB1 gene expression was associated with favorable tumor response (p = 0.012) and prolonged survival (p = 0.081) under cisplatin-based chemotherapy. High SERPINB1 protein expression in tumor tissue from cisplatin-treated patients was associated with a favorable survival (p = 0.011), and proved as an independent pr...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Russell D PettyElaina S R Collie-Duguid
Jun 2, 2006·Genome Biology·Ruby H P LawJames C Whisstock
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Selma UgurelUNKNOWN Dermatologic Cooperative Oncology Group
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward L KornJohn M Kirkwood
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marco J HeroldHolger M Reichardt
May 8, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sanjiv S AgarwalaAlexander M M Eggermont
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Oct 7, 2010·Journal of Clinical Pathology·Katharine A ParkerIan A Cree
Mar 18, 2011·International Journal of Cancer. Journal International Du Cancer·Roland HoubenDavid Schrama
Nov 5, 2011·DNA Repair·Jingyin YueZhiyuan Shen
Mar 16, 2012·International Journal of Biological Sciences·Jingyin YueZhiyuan Shen
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J O'DayAxel Hauschild
May 15, 2013·Journal of Proteomics·M D PastorL Paz-Ares
May 17, 2013·American Journal of Clinical Dermatology·Marta BatusHoward L Kaufman
Jul 23, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander M Menzies, Georgina V Long
Aug 29, 2013·International Journal of Cancer. Journal International Du Cancer·Stephanie B HatchRicky A Sharma
Sep 24, 2013·Lancet·Alexander M M EggermontCaroline Robert
Nov 1, 2013·Human Genomics·Claire HeitVasilis Vasiliou
Jan 15, 2014·American Journal of Therapeutics·Enrique EspinosaDirk Schadendorf
Feb 11, 2014·Journal of the National Cancer Institute·Klaus G GriewankRajmohan Murali
Mar 13, 2014·Cancer Immunology, Immunotherapy : CII·Sander KeldermanChristian U Blank

❮ Previous
Next ❯

Citations

Mar 9, 2018·Scientific Reports·Jia LiuWeiling Li
May 18, 2017·Molecular Cancer Research : MCR·Irina LermanStephen R Hammes
Jan 6, 2019·Molecular Cancer Research : MCR·Irina LermanStephen R Hammes

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
PCR
electrophoresis
density gradient centrifugation
chip

Clinical Trials Mentioned

NCT00779714

Software Mentioned

Primer Express
Affymetrix GeneChip Operating Software ( GCOS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Clinical and Experimental Pathology
Chengzhi HeHengjun Gao
International Journal of Cancer. Journal International Du Cancer
Pierre TennstedtKerstin Borgmann
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Wolfgang A Weber
© 2022 Meta ULC. All rights reserved