Serrated adenomatous polyposis in humans

Gastroenterology
E Torlakovic, D C Snover

Abstract

Hyperplastic polyposis clinically resembles adenomatous polyposis and has not generally been considered precancerous. However, since the original description, a number of cases associated with adenocarcinoma have been reported. The aim of this study was to reevaluate patients previously diagnosed with hyperplastic polyposis. Pathological analysis of polyps in 6 patients with putative hyperplastic polyposis and 4 with associated carcinoma was compared with classic isolated hyperplastic polyps, adenomas, and solitary serrated adenomas. Immunohistochemical study for the detection of p53 protein, blood groups antigens, including Lewis(a) and Lewis(b), and peanut lectin binding was performed. Polyps in our patients were much more similar to serrated adenomas than to hyperplastic polyps and were characterized by large size, prominent architectural distortion, cytologically atypical nuclei, focal nuclear crowding and nuclear dispolarity, and rare upper zone mitotic figures. The polyps in our patients and control serrated adenomas had a decrease or absence of endocrine cells compared with classic hyperplastic polyps and normal colon and similar immunohistochemical reactivity for p53 and Lewis(a) and Lewis(b) antigens. Our results indic...Continue Reading

Citations

Mar 10, 2010·International Journal of Colorectal Disease·Daniel D BuchananJoanne P Young
Nov 10, 2010·Virchows Archiv : an International Journal of Pathology·Michael ViethMauro Risio
Sep 19, 2008·Current Gastroenterology Reports·Rachel J GroffDennis J Ahnen
Dec 17, 2009·Clinics in Colon and Rectal Surgery·Valerie P Bauer, Harry T Papaconstantinou
Apr 19, 2012·The American Journal of Surgical Pathology·Christophe RostyJoanne P Young
Dec 6, 2012·The American Journal of Surgical Pathology·Christophe RostyDaniel D Buchanan
Jul 16, 2002·Gut·E J SawyerI P M Tomlinson
Jun 29, 2004·Journal of Clinical Pathology·T Higuchi, J R Jass
Apr 30, 2009·Annual Review of Pathology·Amy E Noffsinger
Aug 8, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristin WallaceJohn A Baron
Apr 9, 2010·Future Oncology·Daniel D BuchananJoanne P Young
Jan 25, 2012·International Journal of Molecular Sciences·Marianne Berg, Kjetil Søreide
Aug 24, 2013·International Journal of Molecular Sciences·Dora ColussiLuigi Ricciardiello
Jun 21, 2008·World Journal of Gastroenterology : WJG·Hugh-James Freeman
Jun 2, 2012·World Journal of Gastroenterology : WJG·Carla GuarinosRodrigo Jover
Sep 13, 2012·World Journal of Gastroenterology : WJG·Shinya IshigookaFumio Itoh
Feb 23, 2013·World Journal of Gastroenterology : WJG·Arpád V PataiFerenc Sipos
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Rana Bokhary
Jul 9, 2014·The American Journal of Gastroenterology·Jill TinmouthLinda Rabeneck
Jan 11, 2012·Scandinavian Journal of Gastroenterology·Anouar TeriakyNilesh Chande
Oct 29, 2015·International Journal of Cancer. Journal International Du Cancer·Eiji SakaiAtsushi Kaneda
Sep 14, 2011·Expert Review of Gastroenterology & Hepatology·Seth SweetserAravind Sugumar
Feb 6, 2016·International Journal of Colorectal Disease·Guido SchachschalThomas Rösch
Oct 16, 2015·Journal of Clinical Pathology·C A Rubio
Feb 16, 2013·Gastrointestinal Endoscopy·Berkeley N LimketkaiChristina A Arnold
Nov 21, 2012·Annales de pathologie·Jean-François Fléjou
Jun 18, 2011·Pathology, Research and Practice·Mahin MohammadiSusanne Holck
Jun 1, 2010·Surgical Pathology Clinics·Dale C Snover, Kenneth P Batts
Oct 5, 2010·Gastrointestinal Endoscopy Clinics of North America·Dale C Snover
Jul 27, 2010·Gastrointestinal Endoscopy Clinics of North America·Amy E Noffsinger, John Hart
Oct 2, 2009·Surgical Oncology Clinics of North America·Thomas J McGarrity, Christopher Amos
Sep 18, 2009·Gastroentérologie Clinique Et Biologique·J-C Saurin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.