Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings

Genetics
Sheng-An Yang, Wu-Min Deng

Abstract

Drosophila imaginal rings are larval tissues composed of progenitor cells that are essential for the formation of adult foreguts, hindguts, and salivary glands. Specified from subsets of ectoderm in the embryo, imaginal ring cells are kept quiescent until midsecond larval instar, and undergo rapid proliferation during the third instar to attain adequate numbers of cells that will replace apoptotic larval tissues for adult organ formation. Here, we show that Notch signaling is activated in all three imaginal rings from middle embryonic stage to early pupal stage, and that Notch signaling positively controls cell proliferation in all three imaginal rings during the third larval instar. Our mutant clonal analysis, knockdown, and gain-of-function studies indicate that canonical Notch pathway components are involved in regulating the proliferation of these progenitor cells. Both trans-activation and cis-inhibition between the ligand and receptor control Notch activation in the imaginal ring. Serrate (Ser) is the ligand provided from neighboring imaginal ring cells that trans-activates Notch signaling, whereas both Ser and Delta (Dl) could cis-inhibit Notch activity when the ligand and the receptor are in the same cell. In addition, ...Continue Reading

References

Sep 28, 1995·Nature·S JarriaultA Israel
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L L Dobens, L A Raftery
May 30, 2001·Current Opinion in Genetics & Development·C J Potter, T Xu
Jan 19, 2002·Genes & Development·Toby LieberMichael W Young
Nov 26, 2002·Current Biology : CB·Bernard DuvicJulien Royet
Jun 12, 2003·Developmental Biology·Adam S HabermanDeborah J Andrew
Oct 23, 2003·Nature Reviews. Cancer·Freddy Radtke, Kenneth Raj
Dec 6, 2003·The Journal of Cell Biology·Melissa M RollsChris Q Doe
Feb 19, 2004·Science's STKE : Signal Transduction Knowledge Environment·Sean E McGuireRonald L Davis
Apr 6, 2005·Developmental Cell·Antonio Baonza, Matthew Freeman
Sep 2, 2008·Oncogene·R M DemarestA J Capobianco
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
Jun 12, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Madhuri Kango-Singh, Amit Singh
Jul 28, 2009·Nature Methods·Cory J EvansUtpal Banerjee
Mar 17, 2010·Current Biology : CB·Isabelle BecamMarco Milán
Aug 4, 2010·Genesis : the Journal of Genetics and Development·Xiankun ZengSteven X Hou
Jan 11, 2011·Current Biology : CB·David del ÁlamoFrançois Schweisguth
Aug 23, 2011·Experimental Cell Research·Huaqi Jiang, Bruce A Edgar
Feb 15, 2012·Journal of Cell Science·Elena Domanitskaya, Trudi Schüpbach
May 23, 2012·Current Opinion in Genetics & Development·Huaqi Jiang, Bruce A Edgar
Mar 13, 2014·Blood·Camille LobryIannis Aifantis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alagille Syndrome

Alagille syndrome is a multi-system genetic disorder that can affect the liver, heart, and other parts of the body. It’s characterization includes heart problems, liver damage, jaundice, and xanthomas. Here is the latest research.