Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: In-vitro, ex-vivo and in-vivo evaluation

International Journal of Pharmaceutics
Menna M AbdellatifMahmoud A F Khalil

Abstract

The aim of this study was to develop different vesicular systems for sertaconazole nitrate and evaluate the ability of targeting deep skin layers to treat dermal fungal infection. Therefore, different phospholipid based nanovesicles, namely liposomes, glycerosomes, transferosmes and ethosomes were prepared and in-vitro evaluated for morphology, entrapment efficiency, vesicle size and zeta potential value, followed by ex-vivo evaluation through skin penetration and permeation. The selected vesicular formula was incorporated into gel base system and assessed by ex-vivo permeation visualization study using confocal laser scanning microscopy (CLSM). In-vivo study was performed to compare antifungal efficacy of STZL loaded vesicular gel with commercial cream (Dermofix®). All nanovesicles were unilamller and almost spherical in shape. Entrapment efficiency, vesicle size and zeta potential were dependent upon vesicle composition. Vesicular formulae promoted drug permeation compared to commercial cream where transferosomal system containing 3% soyphospholipid (SPC) and 0.15% sodium deoxychloate (SDC) exhibited highest flux (645μg/cm2/h). The CLSM images confirmed the penetration of the developed probe-loaded tansferosomal system to via...Continue Reading

Citations

Jan 18, 2018·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Nataša Z Bubić PajićSnežana D Savić
Dec 12, 2018·Journal of Liposome Research·Malleswara Rao PeramPrakash Diwan
Jan 24, 2020·Antioxidants & Redox Signaling·Abdelouahed KhalilHicham Berrougui
Jul 2, 2020·International Journal of Nanomedicine·Menna M AbdellatifAsmaa K Al-Mokaddem
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sevgi Güngör, Emine Kahraman
Apr 11, 2020·International Journal of Pharmaceutics·Marianne J NaguibShaimaa M Badr-Eldin
May 8, 2020·International Journal of Pharmaceutics·Francesco LaiAnna Maria Fadda
Mar 20, 2021·International Journal of Pharmaceutics·Yara E ElakkadIslam A Khalil
Apr 15, 2021·Colloids and Surfaces. B, Biointerfaces·Mohammed Elmowafy
May 27, 2021·Pharmaceutical Research·Ana Cláudia Paiva-SantosFrancisco Veiga
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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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