Sertindole : a review of its use in schizophrenia

CNS Drugs
David Murdoch, Gillian M Keating

Abstract

Oral sertindole (Serdolect) is an atypical antipsychotic approved in the EU for once-daily use in patients with schizophrenia who are intolerant to at least one other antipsychotic agent. Extensive data from post-marketing studies do not indicate an excess of overall mortality with sertindole. Sertindole is at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS). Thus, sertindole is a useful option in the treatment of patients with schizophrenia.

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Citations

May 10, 2012·Neuropsychiatric Disease and Treatment·Silvio CacciaAlessandro Nobili
Mar 1, 2012·Journal of Clinical Psychopharmacology·Jimmi NielsenDavid Taylor
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·Edoardo Spina, Rocco Zoccali
Nov 18, 2010·Expert Opinion on Pharmacotherapy·Jean-Michel AzorinMarc Adida
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Edoardo Spina, Jose de Leon
Oct 12, 2012·The European Journal of Neuroscience·Silvia FanoUwe Heinemann
Apr 2, 2015·Journal of Clinical Psychopharmacology·Rocco A ZoccaliMaria Rosaria Anna Muscatello

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