Sertoli and Leydig cell numbers and gonadotropin receptors in rat testis from birth to puberty

Cell and Tissue Research
M BortolussiL Colombo

Abstract

In testes of rats from 2 to 60 days of age, we examined the number of Sertoli cells (SC) and Leydig cells (LC) as well as the binding of radioiodinated gonadotropins to frozen sections and homogenates. The number of SC per testis increased only during the first 2 postnatal weeks, whereas that of LC was stable up to days 7-10 and increased thereafter. The uptake of 125I-labelled human follicle-stimulating hormone (125I-FSH) to frozen sections was confined to sex cords or seminiferous tubules, while that of 125I-labelled human choriogonadotropin (125I-hCG) matched the distribution of LC in the interstitium. High affinity receptors for FSH and hCG were found in homogenates at all stages studied. The number of FSH receptors per testis increased steadily, whereas that of hCG receptors was low until days 7-10 and rose afterwards. Thus, SC in rat testis appear to proliferate in the presence of fetal LC during the first 2 postnatal weeks and to differentiate concomitantly with the emergence of the adult LC generation after day 10. The complement of FSH receptors in SC remains constant as they proliferate and increases after day 21 as they differentiate. The hCG receptor number is relatively fixed in each LC generation, being higher in ...Continue Reading

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Citations

Aug 12, 1999·International Journal of Andrology·M B FrungieriR S Calandra
Jul 17, 2001·International Journal of Andrology·R R MaranM M Aruldhas
Sep 5, 2008·Biology of Reproduction·Michelle A Wood, William H Walker
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Apr 1, 1995·Tissue & Cell·L D Russell, L R de França
Nov 5, 2003·Developmental Biology·Buom-Yong RyuRalph L Brinster
Oct 22, 2015·Reproduction, Fertility, and Development·Jenna T HaverfieldSarah J Meachem
Aug 22, 2001·Biology of Reproduction·S M Mendis-Handagama, H B Ariyaratne
Jan 18, 2013·Biology of Reproduction·Pawan Puri, William H Walker
Aug 2, 2012·American Journal of Physiology. Endocrinology and Metabolism·Indrashis BhattacharyaSubeer S Majumdar
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Xiaorui FanJunping He

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