PMID: 18714671Aug 22, 2008Paper

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells

Cell Transplantation
J M DufourR V Rajotte

Abstract

Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell line (MSC-1) in order to identify a Sertoli cell line that could be used to aid in investigation of the immunoprotective abilities of Sertoli cells. BALB/c islets were cotransplanted with 0-9 million primary BALB/c Sertoli cells or MSC-1 cells into diabetic C3H or BALB/c mice and protection of grafted islets was examined by monitoring blood glucose levels and immunohistochemical analysis. Additionally, expression of potential immunoprotective factors in MSC-1 cells was examined. Cotransplantation of islets with 3 million primary Sertoli cells significantly prolonged islet allograft survival (61.1 +/- 6.9 days; p < 0.05) compared with control mice that received allogeneic islets alone (26.9 +/- 2.1 days). Grafts collected from normoglycemic C3H mice at 100 days posttransplant contained insulin-positive beta-cells adjacent to allogeneic Sertoli cells arranged in tubule-like structures. In contrast, cotransplantation of islet allografts with MSC-1 cells did not prolong islet survival (ave...Continue Reading

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Citations

Apr 24, 2012·Asian Journal of Andrology·Thilee SivananthanDavid Handelsman
Oct 14, 2009·The Journal of Experimental Medicine·Francesca FallarinoRiccardo Calafiore
Nov 1, 2011·Pharmacological Reviews·C Yan Cheng, Dolores D Mruk
Aug 20, 2010·Cell Transplantation·Katelyn HalleyJannette M Dufour
Dec 10, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Payal MitalJannette M Dufour
Aug 29, 2014·In Vitro Cellular & Developmental Biology. Animal·Huimin SuYingji Wu
Dec 3, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Nan LiC Yan Cheng
Jul 21, 2015·Tissue Engineering. Part B, Reviews·Daniel T BowersKenneth L Brayman
May 4, 2012·Spermatogenesis·Gurvinder Kaur, Jannette M Dufour
Feb 10, 2012·Spermatogenesis·Yan-Ho ChengC Yan Cheng
May 23, 2015·Journal of Immunology Research·Xiaojie WangKevin J McElwee
Mar 8, 2014·Seminars in Cell & Developmental Biology·Gurvinder KaurJannette M Dufour
Nov 23, 2012·Diabetes·Dirk J van der WindtDavid K C Cooper
Jan 7, 2011·Biology of Reproduction·Payal MitalJannette M Dufour
Nov 9, 2010·Cell Transplantation·Kitty ChuiConstance M John
Apr 19, 2013·Biology of Reproduction·Ajeet Pratap SinghTrevor K Archer
Aug 4, 2020·Molecular Reproduction and Development·Helena D Zomer, Prabhakara P Reddi
Feb 3, 2018·Molecular Medicine Reports·Jiahui ZhangHuabiao Chen
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Feb 4, 2016·Transplantation·Stephen T BartlettTimo Otonkoski
Apr 4, 2021·Biomedicines·Rachel L WashburnJannette M Dufour

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