Sertoli cell markers in the diagnosis of paediatric male hypogonadism

Journal of Pediatric Endocrinology & Metabolism : JPEM
Romina P GrinsponRodolfo A Rey

Abstract

During childhood, the pituitary-testicular axis is partially dormant: testosterone secretion decreases following a drop in luteinising hormone levels; follicle-stimulating hormone (FSH) levels also go down. Conversely, Sertoli cells are most active, as revealed by the circulating levels of anti-Müllerian hormone (AMH) and inhibin B. Therefore, hypogonadism can best be evidenced, without stimulation tests, if Sertoli cell function is assessed. Serum AMH is high from fetal life until mid-puberty. Testicular AMH production increases in response to FSH and is potently inhibited by androgens. Inhibin B is high in the first years of life, then decreases partially while remaining clearly higher than in females, and increases again at puberty. Serum AMH and inhibin B are undetectable in anorchid patients. In primary or central hypogonadism affecting the whole gonad established in fetal life or childhood, all testicular markers are low. Conversely, when hypogonadism only affects Leydig cells, serum AMH and inhibin B are normal. In males of pubertal age with central hypogonadism, AMH and inhibin B are low. Treatment with FSH provokes an increase in serum levels of both Sertoli cell markers, whereas human chorionic gonadotrophin (hCG) adm...Continue Reading

Citations

Aug 12, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·S GiovagnoliR Calafiore
Nov 5, 2013·Fertility and Sterility·Edward DereKim Boekelheide
Dec 17, 2015·European Journal of Endocrinology·Romina P GrinsponRodolfo A Rey
Nov 17, 2015·Endocrinology and Metabolism Clinics of North America·Shanlee M DavisJudith L Ross
Jul 26, 2015·BMC Veterinary Research·Bodil S Holst, Ulrika Dreimanis
Dec 25, 2013·International Journal of Endocrinology·Marie Lindhardt JohansenAnders Juul
Dec 12, 2012·The Journal of Clinical Endocrinology and Metabolism·Rodolfo A Rey
Jun 17, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Shanlee M DavisJudith L Ross
Dec 9, 2014·The Journal of Clinical Endocrinology and Metabolism·Evelien E J W SmeetsHedi L Claahsen-van der Grinten
May 24, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mona HafezAlaa Abd Al Hamid
Jun 21, 2018·Frontiers in Endocrinology·Romina P GrinsponRodolfo A Rey
Apr 4, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Clara ValeriRodolfo A Rey
May 5, 2021·Expert Review of Molecular Diagnostics·Xu YouHaixia Zhao
Jul 23, 2013·Annals of Clinical Biochemistry·Channa N JayasenaWaljit S Dhillo

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