Sertoli cells in testes containing or lacking germ cells: a comparative study of paracrine effects using the W (c-kit) gene mutant mouse model

The Anatomical Record
L R De FrancaL D Russell


Paracrine effects of germ cells on Sertoli cell structure were examined in a mouse model with the W locus (dominant white spotting) mutation in which animals with the W/Wv genotype (referred to as mutants) lack virtually all germ cells. Morphometric determination of Sertoli cell parameters in mutant and control (+/+) animals showed that although the testes of mutant animals were about eight times smaller than controls, the numbers of Sertoli cells in the two groups did not differ. Sertoli cell volume, Sertoli cell cytoplasmic and nuclear volumes, and Sertoli cell surface area in mutant animals were significantly smaller than in control animals. Organelle volumes and surface areas, expressed per cell, did not differ significantly in the two groups with one exception: the volume and surface area of smooth endoplasmic reticulum was significantly reduced in mutant animals. Plasma testosterone levels and tissue testosterone levels/testis were normal, indicating that the effects observed in the mutant animal were not a consequence of androgen insufficiency. Plasma FSH was elevated, probably as a consequence of germ cell depletion, and was thought not to affect Sertoli cell parameters observed. The data suggest that paracrine interact...Continue Reading


Feb 1, 1991·Endocrine Reviews·M K Skinner
Jan 1, 1987·Journal of Steroid Biochemistry·J M SaezM A Rivarola
Feb 1, 1986·Clinics in Endocrinology and Metabolism·R M Sharpe
Jan 1, 1985·International Review of Cytology·L D Russell, R N Peterson
Jan 1, 1986·Journal of Reproduction and Fertility·H P Bugge, L Plöen
Mar 1, 1957·The Journal of Experimental Zoology·B MINTZ, E S RUSSELL

❮ Previous
Next ❯


Mar 1, 2002·Brain Research. Molecular Brain Research·Xue Ying HeSong Yu Yang
Mar 16, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C A StrüssmannF Takashima
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·D Leanne Jones, Amy J Wagers
Aug 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michelle WelshLee B Smith
Apr 4, 2008·The Journal of Reproduction and Development·Maryam KhalajTetsuo Kunieda
May 3, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Jose R Rodriguez-SosaIna Dobrinski
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·P J O'ShaughnessyP J Baker
Oct 9, 2015·Andrology·L B SmithD Rebourcet
Jun 8, 2002·Developmental Biology·Kiyoko TanakaTakahiko Hara
Jan 11, 2002·Developmental Biology·A J RossG R MacGregor
Mar 20, 2002·Mechanisms of Development·Yuko TadokoroYoshitake Nishimune
Aug 17, 2016·Scientific Reports·Sutada Lotinun, Nateetip Krishnamra
Jun 25, 2002·Biology of Reproduction·Elizabeth S NevesLuiz R França
Nov 26, 1998·Biology of Reproduction·G G ParreiraL D Russell
Aug 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yuna Kim, Blanche Capel
Sep 11, 2001·The Journal of Experimental Zoology·A ShinomiyaN Shibata
Jul 4, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Junko WakabayashiMasayuki Yamamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.