Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

BMC Neurology
Jieun ChoiJeon-Soo Shin

Abstract

The search for noninvasive biomarkers of neuroinflammation and neurodegeneration has focused on various neurological disorders, including epilepsy. We sought to determine whether α-synuclein and cytokines are correlated with the degree of neuroinflammation and/or neurodegeneration in children with epilepsy and with acquired demyelinating disorders of the central nervous system (CNS), as a prototype of autoimmune neuroinflammatory disorders. We analyzed serum and exosome levels of α-synuclein and serum proinflammatory and anti-inflammatory cytokines among 115 children with epilepsy and 10 acquired demyelinating disorders of the CNS and compared to 146 controls. Patients were enrolled prospectively and blood was obtained from patients within 48 h after acute afebrile seizure attacks or relapse of neurological symptoms. Acquired demyelinating disorders of the CNS include acute disseminated encephalomyelitis, multiple sclerosis, neuromyelitis optica spectrum disorders, and transverse myelitis. The controls were healthy age-matched children. The serum exosomes were extracted with ExoQuick exosome precipitation solution. Serum α-synuclein levels and serum levels of cytokines including IFN-β, IFN-γ, IL-1β, IL-6, IL-10 and TNF-α were m...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Sara Monteiro-ReisCarmen Jerónimo
Apr 27, 2021·Journal of Neuroscience Methods·Jorge M Ortega IbarraAlberto Morales-Villagrán
Aug 6, 2021·Neuropsychiatric Disease and Treatment·Lan ShenYueling Tang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
blood collection

Software Mentioned

GraphPad

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