Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2  and D3 Supplementation in patients with chronic kidney disease on hemodialysis

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Laura A Graeff-ArmasGlenville Jones

Abstract

While vitamin D deficiency is common in patients with end stage renal disease on dialysis and treatment with Vitamin D2 and Vitamin D3 is becoming increasingly common in these patients, little is known about 24,25(OH)2D3 metabolite production. Some authors report that the CYP24A1 enzyme is upregulated in CKD, but reports of low serum levels of 24,25(OH)2D3 in these patients bring this into question. Lack of substrate or increased clearance of the metabolite have been proposed as possible causes. We report serum 24,25(OH)2D3 levels from three controlled trials of Vitamin D2 and Vitamin D3 supplementation which reached adequate levels of 25(OH)D in patients with end stage renal disease on dialysis. 680 samples from three controlled trials of Vitamin D2 or Vitamin D3 supplementation in CKD Stage 5D were available for analysis. The trials used single doses of 50,000 IU Vitamin D3, or 50,000 IU Vitamin D2, or weekly doses of 10,000 IU or 20,000 IU Vitamin D3. Blood samples were drawn at baseline and frequently over the ensuing 3-4 months. Serum 25(OH)D and 24,25(OH)2D3 levels were measured using a novel, very sensitive LC-MS/MS-based method involving derivatization with DMEQ-TAD. Linear mixed effect regression models were used to co...Continue Reading

Citations

Aug 29, 2017·Expert Review of Clinical Pharmacology·Andrea GalassiMario Cozzolino
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shaojing YuZhengce Wan
Apr 16, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin KaufmannGlenville Jones

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