Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis

BMC Infectious Diseases
Yuye Li, Shifang Ding

Abstract

Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mortality risk in adult patients in a meta-analysis. Follow-up studies that provided data of multivariate adjusted relative risk (RR) between serum 25 (OH) D and mortality risk in septic patients were retrieved via systematic search of PubMed and Embase databases. A random effect model was used to pool the results. Eight studies with 1736 patients were included. Results of overall meta-analysis showed that lower 25 (OH) D at admission was independently associated with increased risk or mortality (adjusted RR: 1.93, p < 0.001; I2 = 63%) in patients with sepsis. Exploring subgroup association showed that patients with severe vitamin D deficiency (25 (OH) D < 10 ng/ml) was significantly associated with higher mortality risk (adjusted RR: 1.92, p < 0.001), but the associations were not significant for vitamin D insufficiency (25 (OH) D 20~30 ng/ml) or deficiency (25 (OH) D 10~20 ng/ml). Further analyses showed that the association b...Continue Reading

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Citations

Sep 2, 2020·Journal of the American College of Nutrition·Navya VyasSonal Sekhar Miraj
Jan 21, 2021·International Journal of Environmental Research and Public Health·Joji AbrahamSingarayer Florentine
May 1, 2021·Medicina·Alberto Tosoni On Behalf Of The Internal Medicine Sepsis Study Group
May 14, 2021·The Journal of Nutrition·Mikhail V BychininAleksandr V Troitsky

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