Serum 25-hydroxyvitamin D concentrations and risk for hip fractures.

Annals of Internal Medicine
Jane A CauleySteven R Cummings

Abstract

The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear. To see whether low serum 25(OH) vitamin D concentrations are associated with hip fractures in community-dwelling women. Nested case-control study. 40 clinical centers in the United States. 400 case-patients with incident hip fracture and 400 control participants matched on the basis of age, race or ethnicity, and date of blood draw. Both groups were selected from 39 795 postmenopausal women who were not using estrogens or other bone-active therapies and who had not had a previous hip fracture. Serum 25(OH) vitamin D was measured and patients were followed for a median of 7.1 years (range, 0.7 to 9.3 years) to assess fractures. Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]). Women with the lowest 25(OH) vitamin D concentrations (< or =47.5 nmol/L) had a higher fracture risk than did those with the highest concentrations (> or =70.7 nmol/L) (adjus...Continue Reading

References

Dec 1, 1988·American Journal of Obstetrics and Gynecology·F Z StanczykR A Lobo
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·M E OomsP Lips
Oct 1, 1993·Health Economics·R D HaysR M Mazel
Mar 20, 1998·The New England Journal of Medicine·M K ThomasJ S Finkelstein
Apr 7, 1999·Annals of Epidemiology·R E PattersonT Agurs-Collins
May 5, 1999·JAMA : the Journal of the American Medical Association·M S LeBoffJ Glowacki
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Mar 24, 2000·Endocrine-related Cancer·N M Probst-HenschB E Henderson
Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P Mezquita-RayaF Escobar-Jiménez
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Sep 6, 2002·The New England Journal of Medicine·JoAnn E MansonDavid S Siscovick
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·E M ColinH A P Pols
Oct 25, 2003·Annals of Epidemiology·Garnet L AndersonRoss L Prentice
Oct 25, 2003·Annals of Epidemiology·Jennifer HaysJacques E Rossouw
Oct 25, 2003·Annals of Epidemiology·J David CurbUNKNOWN WHI Morbidity and Mortality Committee
Apr 20, 2004·The American Journal of Medicine·Heike A Bischoff-FerrariBess Dawson-Hughes
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariJohn B Wong
Oct 27, 2004·Age and Ageing·Jugdeep K DhesiTheresa J Allain
Mar 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P GerdhemK Akesson
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAnne E de Papp
Apr 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Marieke B SnijderPaul Lips
May 12, 2005·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariBess Dawson-Hughes
Aug 5, 2005·Journal of the American Geriatrics Society·Nancy Fugate WoodsUNKNOWN Women's Health Initiative
Feb 17, 2006·The New England Journal of Medicine·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Jan 18, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Heike A Bischoff-Ferrari
Jan 24, 2007·Archives of Internal Medicine·Kristine E EnsrudUNKNOWN Osteoporotic Fractures Research Group
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jul 20, 2007·European Journal of Clinical Investigation·B Kestenbaum, V Belozeroff
Aug 25, 2007·American Journal of Epidemiology·Andrew W RoddamTimothy J Key
Aug 30, 2007·Critical Reviews in Eukaryotic Gene Expression·Dalia Somjen
Oct 3, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne C Looker, Michael E Mussolino

❮ Previous
Next ❯

Citations

Nov 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K E BarbourUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Apr 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J C MenantS R Lord
Apr 19, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M KauppiA Jula
Feb 3, 2011·Calcified Tissue International·Mika YamauchiToshitsugu Sugimoto
Jul 29, 2010·Breast Cancer Research and Treatment·Daniel Prieto-AlhambraXavier Nogues
Mar 22, 2012·Breast Cancer Research and Treatment·Daniel Prieto-AlhambraXavier Nogues
Sep 9, 2010·Journal of General Internal Medicine·Eleanor Bimla SchwarzJudith M E Walsh
Nov 27, 2008·Current Osteoporosis Reports·Rebecca D JacksonWalter Jerry Mysiw
Jan 18, 2012·Current Osteoporosis Reports·Sunil J Wimalawansa
Apr 30, 2010·Current Rheumatology Reports·Nancy E Lane
Jun 13, 2012·Current Treatment Options in Cardiovascular Medicine·Jacqueline S Danik, Joann E Manson
Jan 24, 2012·The British Journal of Nutrition·Kimberly A BertrandDiane Feskanich
Nov 22, 2013·The New England Journal of Medicine·Camille E PoweRavi Thadhani
Mar 2, 2012·Journal of Orthopaedic Trauma·Earl R BogochRobert G Josse
Aug 8, 2014·Obstetrical & Gynecological Survey·Norman B DuerbeckJillinda M Duerbeck
Feb 26, 2013·PloS One·Nicola NapoliUNKNOWN IMDIAB Group
May 13, 2014·BoneKEy Reports·Peter R Ebeling
Jun 22, 2010·Current Osteoporosis Reports·Joop P W van den BerghPiet P Geusens
May 20, 2014·Best Practice & Research. Clinical Rheumatology·Natasha M Appelman-Dijkstra, Socrates E Papapoulos
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Gerome V EscotaWilliam G Powderly
Aug 12, 2014·International Journal of Endocrinology·Nicola NapoliEnrico Carmina
May 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristine E EnsrudUNKNOWN Osteoporotic Fractures in Men Study Group
Oct 24, 2009·Arthritis Research & Therapy·Kenneth G Saag, Piet Geusens
Feb 6, 2010·The Journal of Clinical Endocrinology and Metabolism·John S Adams, Martin Hewison
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A HanleyUNKNOWN Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Praveen KandulaSankar D Navaneethan
Dec 17, 2010·The Journal of Clinical Endocrinology and Metabolism·A J SaiJ C Gallagher
Feb 10, 2011·American Journal of Epidemiology·Dawn C MackeyUNKNOWN Osteoporotic Fractures in Men Research Group
Feb 7, 2013·The Journal of Clinical Endocrinology and Metabolism·J Christopher GallagherLynette M Smith
Apr 26, 2013·The American Journal of Clinical Nutrition·Michael C SachsIan H de Boer
Oct 5, 2011·The Journal of Nutrition, Health & Aging·T DinizuluE Mulkerrin
Aug 5, 2009·Current Medical Research and Opinion·R RizzoliJ -Y Reginster
Jul 14, 2009·The American Journal of the Medical Sciences·Syed H RazaLaura D Carbone
Aug 28, 2013·Advances in Chronic Kidney Disease·L Tammy Ho, Stuart M Sprague
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Luisella Cianferotti, Claudio Marcocci
Apr 25, 2012·Rheumatic Diseases Clinics of North America·Neil BinkleyDiane Krueger

❮ Previous
Next ❯

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