Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study

The European Respiratory Journal
Yi-Qian SunXiao-Mei Mai

Abstract

We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol·L-1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 2...Continue Reading

References

Apr 6, 2006·Journal of the National Cancer Institute·Edward GiovannucciWalter C Willett
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Apr 11, 2008·The American Journal of Clinical Nutrition·Joseph E Zerwekh
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Inger Kristin LarsenBjørn Møller
Apr 27, 2010·Human Molecular Genetics·Jiyoung AhnDemetrius Albanes
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Natasja M van Schoor, Paul Lips
Sep 18, 2012·BMC Medical Research Methodology·Arnulf LanghammerJostein Holmen
Sep 22, 2012·Science·Kai Kupferschmidt
Nov 20, 2012·Science·Stefan PilzJacqueline M Dekker
Mar 19, 2013·Clinical Chemistry·Shoaib AfzalBørge G Nordestgaard
Sep 26, 2013·International Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Oct 12, 2013·Genetic Epidemiology·Stephen BurgessSimon G Thompson
Apr 8, 2014·Nature Reviews. Cancer·David FeldmanBrian J Feldman
May 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Liqun ZhangXuehui Li
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Feb 27, 2016·Journal of Cancer·Elizabeth T JacobsPeter W Jurutka
Jul 2, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ting-Yuan David ChengMary E Reid
Aug 23, 2016·Nature Genetics·Shane McCarthyUNKNOWN Haplotype Reference Consortium
Aug 30, 2016·Nature Genetics·Sayantan DasChristian Fuchsberger
Apr 12, 2017·International Journal of Epidemiology·Olena O Yavorska, Stephen Burgess
Aug 11, 2017·International Journal of Cancer. Journal International Du Cancer·Mackenzie E Fowler, Tomi F Akinyemiju
Oct 14, 2017·Biostatistics·Stijn VansteelandtTorben Martinussen
Oct 31, 2017·Nature Genetics·Manuel A FerreiraLavinia Paternoster
Nov 2, 2017·BMJ : British Medical Journal·Vasiliki I DimitrakopoulouJoellen M Schildkraut

❮ Previous
Next ❯

Citations

Jun 9, 2018·The European Respiratory Journal·Om P Kurmi
Oct 16, 2018·Endocrine Reviews·Roger BouillonJohn Bilezikian
Jul 31, 2019·Genes·Isabel S CarvalhoManuel C Lemos
Aug 20, 2021·Psychiatric Genetics·Yan-Xin WeiCun-Xian Jia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.