Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Michelle ShardellLuigi Ferrucci

Abstract

The hormone klotho is encoded by aging-suppressor gene klotho and has multiple roles, including regulating mineral (calcium and phosphate) homeostasis. Vitamin D also regulates mineral homeostasis and upregulates klotho expression. Klotho positively relates to longevity, upper-extremity strength, and reduced disability in older adults; however, it is unknown whether circulating klotho relates to lower-extremity physical performance or whether the relation of vitamin D with physical performance is mediated by klotho. Klotho and 25-hydroxyvitamin D [25(OH)D] were measured in 860 participants aged ≥ 55 years in Invecchiare in Chianti, "Aging in Chianti" (InCHIANTI), a prospective cohort study comprising Italian adults. Lower-extremity physical performance was measured using the Short Physical Performance Battery, a summary score of balance, chair stand ability, and walking speed. Weighted estimating equations related plasma klotho and serum 25(OH)D concentrations measured at one visit to Short Physical Performance Battery measured longitudinally at multiple visits. Each additional natural log of klotho (pg/mL) was associated with 0.47 higher average Short Physical Performance Battery scores (95% confidence interval: 0.08 to 0.86, ...Continue Reading

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Citations

Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Oct 21, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Oct 10, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ruibin WangMichelle M Estrella
Mar 8, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amin CheikhiFabrisia Ambrosio
Aug 1, 2020·QJM : Monthly Journal of the Association of Physicians·M Verdoia, G De Luca
Feb 28, 2020·International Journal of Environmental Research and Public Health·Akira SaitoYugo Shibagaki
Mar 12, 2021·Hemodialysis International·Barbara Perez Vogt, Jacqueline Costa Teixeira Caramori

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