Abstract
The associations of serum 25-hydroxyvitamin D [25(OH)D] with plasma lipids remain controversial in children. To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children. Cross-sectional. Kuopio, Finland. Population sample of 419 prepubertal white children aged 6 to 8 years. 25(OH)D, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Serum 25(OH)D was negatively associated with total cholesterol (β = -0.141, P = 0.004), LDL cholesterol (β = -0.112, P = 0.023), HDL cholesterol (β = -0.150, P = 0.002), and triglycerides (β = -0.104, P = 0.035) adjusted for age and sex. Associations of 25(OH)D with total cholesterol, LDL cholesterol, and HDL cholesterol remained after adjustment for adiposity, physical activity, sedentary behavior, diet, daylight time, and parental education. Children in the highest quartile of 25(OH)D had the lowest total cholesterol (P = 0.022) and LDL cholesterol (P = 0.026) adjusted for age and sex. Cytochrome P450 family 2 subfamily R member 1 (CYP2R1) rs12794714, CYP2R1 rs10741657, and vitamin D binding protein (DBP) rs2282679 were associated with 25(OH)D adjusted for age and sex. CYP2R1 rs1...Continue Reading
References
Jun 6, 1998·The New England Journal of Medicine·G S BerensonW A Wattigney
May 16, 2002·International Journal of Sports Medicine·T A NicklasG S Berenson
Sep 1, 2004·Mechanisms of Ageing and Development·Motoji SawabeUNKNOWN Japan Science and Technology Agency
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Mar 20, 2010·The Journal of Nutrition·Edgard E DelvinGilles Paradis
Apr 27, 2010·Human Molecular Genetics·Jiyoung AhnDemetrius Albanes
Jun 15, 2010·Lancet·Thomas J WangTimothy D Spector
Sep 22, 2010·Annals of Medicine·Antti SaariLeo Dunkel
Mar 23, 2011·Acta Paediatrica·K ArnbergC Mølgaard
Mar 30, 2011·Journal of the American Dietetic Association·A Catharine RossSue A Shapses
May 7, 2011·Obesity·Ambika P AshrafKenneth L McCormick
May 27, 2011·The American Journal of Clinical Nutrition·Vijay GanjiVin Tangpricha
Jun 7, 2011·Progress in Lipid Research·Rolf Jorde, Guri Grimnes
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jul 15, 2011·European Journal of Endocrinology·L PacificoC Chiesa
Jul 22, 2011·The American Journal of Clinical Nutrition·Molly M LambKatherine M Flegal
Jul 26, 2011·The Journal of Pediatrics·Jennifer SacheckChristina Economos
Dec 2, 2011·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Darren R BrennerAlaa Badawi
Feb 1, 2012·Annals of Nutrition & Metabolism·Hans HaunerUNKNOWN German Nutrition Society
Feb 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Dylan M WilliamsDebbie A Lawlor
Nov 15, 2012·Circulation. Cardiovascular Quality and Outcomes·Lu WangHoward D Sesso
Nov 28, 2012·European Journal of Preventive Cardiology·Dylan M WilliamsDebbie A Lawlor
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel W NebertWalter L Miller
Jan 10, 2013·Clinical Pediatrics·Diana H DolinskyAlex R Kemper
Jan 17, 2013·Journal of Epidemiology and Community Health·Laura D HoweCarol Propper
Mar 5, 2013·Atherosclerosis·Karani S VimaleswaranElina Hyppönen
Jun 6, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C SunT Dwyer
Jun 25, 2013·Mayo Clinic Proceedings·Arash Hossein-nezhad, Michael F Holick
Oct 1, 2013·BMC Endocrine Disorders·Lydia FoucanJacques Ducros
Oct 16, 2013·Medicine and Science in Sports and Exercise·Eero A HaapalaTimo A Lakka
Dec 25, 2013·Gastroenterology·Edwin C Y ChowK Sandy Pang
Jan 1, 2014·European Journal of Nutrition·A M ElorantaT A Lakka
Feb 15, 2014·International Journal of Food Sciences and Nutrition·Roya KelishadiMaryam Bahreynian
Mar 4, 2014·Diabetes & Metabolism·K S VimaleswaranE Hyppönen
Apr 29, 2014·The International Journal of Behavioral Nutrition and Physical Activity·Juuso VäistöTimo A Lakka
Aug 19, 2015·Nutrition·Jung Hyun KwonHae Soon Kim
Sep 19, 2015·The British Journal of Nutrition·Rikke A PetersenCamilla T Damsgaard
Feb 3, 2016·The British Journal of Nutrition·Sonja SoininenTimo A Lakka
Aug 3, 2016·The British Journal of Nutrition·Sonja SoininenTimo A Lakka
Feb 13, 2018·European Journal of Clinical Nutrition·Rolf Jorde, Guri Grimnes