Serum 25-hydroxyvitamin D predict prognosis in radioiodine therapy of Graves' disease

Journal of Endocrinological Investigation
X LiX Fang

Abstract

To investigate serum 25-hydroxyvitamin D 25(OH)D status and assess the predictability of outcome in patients with Graves' disease (GD) who received a patient-specific calculated dose of radioiodine therapy (RIT). 128 patients with GD who received RIT from July 2010 to September 2010 were included. Pre-therapy serum levels of 25(OH)D, calcium, phosphorus, parathyroid hormone, free triiodothyronine, free thyroxine, thyroid stimulating hormone and creatinine were measured. 60 age- and BMI-matched healthy subjects were chosen as the normal control group. Post-therapy follow-up results revealed that therapy failed in 25.00 % of the patients. Serum 25(OH)D levels were found to be significantly lower in patients who failed in therapy. The prevalence of vitamin D deficiency in GD patients was significantly higher compared with control subjects (56.25 vs. 10.00 %, P < 0.001), and therapy failed in 27 (37.50 %) of these patients whose serum 25(OH)D levels < 20 ng/ml. Out of the 56 patients (43.75 %) in whom serum 25(OH)D levels ≥20 ng/ml, therapy was unsuccessful in only 5 (8.93 %). Cox regression analysis suggested that serum 25(OH)D levels <20 ng/ml might be an independent risk factor for predicting failure of RIT in GD patients (relat...Continue Reading

References

Oct 1, 1991·Immunological Reviews·R L CoffmanR Chatelain
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·L WartofskyM Izumi
Feb 1, 1991·Acta Endocrinologica·H BlomgrenL V von Stedingk
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·A AllahabadiaJ A Franklyn
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H F Deluca, M T Cantorna
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Erik K Alexander, P Reed Larsen
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Judith E Kalinyak, I Ross McDougall
Jul 10, 2003·Autoimmunity Reviews·Glinda S Cooper, Berrit C Stroehla
Dec 9, 2004·The American Journal of Clinical Nutrition·Margherita T CantornaAnja Wittke
Jul 28, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Evelyne van Etten, Chantal Mathieu
Apr 30, 2010·Current Opinion in Pharmacology·Femke BaekeChantal Mathieu
Apr 12, 2011·Calcified Tissue International·Stuart H RalstonUNKNOWN FOCUS-D (FOSAVANCE vs. Standard Care-Use and Study of Vitamin D) Trial
Jul 15, 2011·Thyroid : Official Journal of the American Thyroid Association·Gonca TamerDamla Coksert
May 31, 2012·Endocrine·Donald S A McLeod, David S Cooper
Jun 7, 2012·Nuclear Medicine Communications·Serkan IsgorenFatma Berk
Sep 18, 2012·Endocrine·Tetsuyuki YasudaIichiro Shimomura
Dec 10, 2013·Journal of Endocrinological Investigation·H R Song, C H Park
Apr 4, 2014·Journal of Endocrinological Investigation·Elisabetta RomagnoliSalvatore Minisola

❮ Previous
Next ❯

Citations

May 27, 2015·Nutrients·Mei-Yan XuQing-Bin Lu
Jan 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Yu-Ru MaHuai-Dong Song
Sep 17, 2020·Nutrients·Inês Henriques VieiraIsabel Paiva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.