Serum 25-hydroxyvitamin D predicts cognitive performance in adults

Neuropsychiatric Disease and Treatment
Hala DarwishSamia J Khoury

Abstract

Vitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups. In this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30-60 years) adults. Subjects' characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test. Pearson's correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults. These findings suggest that correction of vitamin D needs to be explored as an intervention...Continue Reading

Citations

Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Elżbieta KuźmaDavid J Llewellyn
Mar 19, 2016·Trends in Neurosciences·Catherine LarochelleFrauke Zipp
Jun 25, 2016·Nature Reviews. Neurology·Randi J Hagerman, Paul Hagerman
Apr 5, 2017·Scientific Reports·Hala DarwishSamia Khoury
Mar 6, 2018·Journal of Nutrition in Gerontology and Geriatrics·Laurel KilpatrickKaycee M Sink
Jun 13, 2018·The Clinical Neuropsychologist·Hala DarwishSouha Fares
Feb 19, 2019·Nutritional Neuroscience·Marouan ZoghbiJocelyne Azar
Mar 8, 2019·Nutritional Neuroscience·Natalia PalaciosKatherine L Tucker
Aug 2, 2017·Journal of the American Geriatrics Society·Alicia M Goodwill, Cassandra Szoeke
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May 15, 2021·Current Opinion in Neurology·Randi Hagerman, Paul Hagerman

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