Serum 8-hydroxy-guanine levels are increased in diabetic patients

Diabetes Care
C S ShinH K Lee

Abstract

The production of reactive oxygen species is increased in diabetic patients, especially in those will poor glycemic control. We have investigated oxidative damage in type 2 diabetic patients using serum 8-hydroxyguanine (8-OHG) as a biomarker. We studied 41 type 2 diabetic patients and compared them with 3 nondiabetic control subjects. Serum 8-OHG concentration was assayed using high-pressure liquid chromatography. The type 2 diabetic patients had significantly higher concentrations of 8-OHG in their serum than the control subjects (5.03 +/- 0.69 vs. 0.96 +/- 0.15 pmol/ml P < 0.01). There was no association between the levels of 8-OHG and HbA1c. We also could not and any correlation between serum 8-OHG levels and age, duration of diabetes, serum lipids, or creatinine or albumin exeretion rate. Creatinine clearance showed marginal correlation with serum 8-OHG levels (P = 0.06). Among the diabetic patients, those with proliferative retinopathy had significantly higher 8-OHG levels than those with nonproliferative retinopathy or without retinopathy. Likewise, the serum 8-OHG levels in patients who had advanced nephropathy (azotemia) were higher than in patients with normoalbuminuria, microalbuminuria, or overt proteinuria. Our fin...Continue Reading

References

Jul 1, 1992·Diabetes Care·M I HarrisM W Knuiman
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E M ParkB N Ames
Jan 1, 1991·Free Radical Biology & Medicine·D Armstrong, F al-Awadi
Jan 1, 1989·Free Radical Research Communications·B N Ames
May 1, 1989·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y NagasakaT Kaneko
Apr 1, 1980·Diabetes·M KitaharaH R Hill
Nov 15, 1982·Biochemical Pharmacology·W J Malaisse
Feb 1, 1994·Free Radical Biology & Medicine·H HaK H Kim
Oct 1, 1993·Journal of Toxicology and Environmental Health·S LoftH E Poulsen
Jan 1, 1995·International Journal of Clinical & Laboratory Research·T OzbenN Tuncer
Feb 17, 1996·Lancet·P DandonaT Nicotera
Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Jul 29, 1998·Free Radical Biology & Medicine·I GrattaglianoE Altomare
Nov 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K Z Kedziora-KornatowskaW Pawlak

❮ Previous
Next ❯

Citations

Mar 17, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria Grazia AndreassiEugenio Picano
Jul 24, 2010·Pflügers Archiv : European journal of physiology·Gisela DrewsMartina Düfer
Feb 12, 2010·Cancer Causes & Control : CCC·Gabriel ChodickVarda Shalev
Jul 22, 2005·Current Diabetes Reports·Xinhua Chen, Theresa O Scholl
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lily L WuJames T Wu
Sep 3, 2004·Mutation Research·Mark D EvansMarcus S Cooke
Apr 23, 2003·Molecular and Cellular Endocrinology·Patricia MerkelRiccardo Perfetti
Dec 19, 2002·Free Radical Biology & Medicine·Marcus S CookeMark D Evans
Dec 18, 2010·Mutagenesis·Maria Grazia AndreassiEugenio Picano
Aug 27, 2005·Clinical and Experimental Pharmacology & Physiology·Gülnur Andican, Gülden Burçak
Oct 6, 2004·Kidney International. Supplement·Sudhir V Shah
Nov 26, 2013·Biochemia Medica·Simona Cernea, Minodora Dobreanu
Dec 1, 2007·Endocrine Reviews·Vincent Poitout, R Paul Robertson
Aug 4, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Hui YangSheng-Kai Yan
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Roberta Passos PalazzoSharbel Weidner Maluf
Nov 14, 2012·Expert Review of Hematology·Prajwal GyawaliEzekiel Uba Nwose
Feb 23, 2011·Archives of Physiology and Biochemistry·Lukáš PácalKateřina Kaňková
Apr 17, 2007·FEBS Letters·R Paul Robertson, Jamie S Harmon
Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Aleksei V ErmakovNatalya N Veiko
Nov 15, 2011·Diabetes Research and Clinical Practice·Suresh K G ShettigarRatnakar K Kulkarni
Nov 26, 2008·Journal of Proteomics·Yannick BrunnerJean-Charles Sanchez
Jun 2, 2007·The International Journal of Biochemistry & Cell Biology·Antonysunil AdaikalakoteswariMuthuswamy Balasubramanyam
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·S W ChoiJ J Strain
Sep 29, 2004·Mutation Research·Janusz BlasiakJozef Drzewoski
Jul 11, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Sudhir V Shah
Jul 4, 2006·Free Radical Biology & Medicine·R Paul Robertson, Jamie S Harmon
Sep 18, 2012·Toxicology Mechanisms and Methods·Mohan M RajapurkarSudhir V Shah
May 13, 2014·European Journal of Nutrition·Lucia LaubertováIngrid Zitňanová
Mar 25, 2016·The Journal of International Medical Research·Xiaozhen YeHong Du
May 2, 2017·Journal of Cellular Biochemistry·Kanwal Rehman, Muhammad Sajid Hamid Akash
Sep 18, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Nicole Noren HootenMichele K Evans

❮ Previous
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