Serum 90K/Mac-2 binding protein (Mac-2BP) as a response predictor to peginterferon and ribavirin combined treatment in HCV chronic patients

Immunopharmacology and Immunotoxicology
P A IacovazziM Correale

Abstract

90K/Mac-2BP glycoprotein is involved in the immune defense against a variety of neoplasms and viral infections, modulating the activity of several effectors such as natural killer cells. Quite interestingly, 90K/Mac-2BP is associated to a poor response to interferon (IFN) alpha in hepatitis C virus (HCV) infected patients. Here, in 70 consecutive HCV chronic patients, we have evaluated 90K basal levels as a response predictor to combined therapy with Peginterferon and Ribavirin. We have found higher 90K levels in genotype 1/4 than in genotype 2/3 (p = 0.006) and in 62.5% of non-responders than in 20% of responders (p < 0.001). Genotype 1/4, higher 90K and gamma glutamyl transferase (gammaGT) levels resulted independently associated to a status of refractoriness to therapy. Consequently, evaluation of 90K serum levels seems to be a promising useful marker of response to combined therapy in HCV disease.

References

Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·S IacobelliS Mancuso
Sep 1, 1993·AIDS Research and Human Retroviruses·N C BriggsS Iacobelli
May 1, 1995·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·T J PowellL K Shawver
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L Davis, J Y Lau
Apr 13, 1999·Genomics·C BrakebuschA Ullrich
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PoynardJ Albrecht
Apr 9, 2001·Clinics in Liver Disease·E BarnesG Dusheiko
Jan 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·P A IacovazziM Correale
Dec 25, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gloria TalianiMario Clerici
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas BergStefan Zeuzem
Sep 16, 2005·Pigment Cell Research·Sébastien Corre, Marie-Dominique Galibert
Apr 19, 2006·Gastroenterology·Gloria TalianiUNKNOWN Nonresponder Retreatment Group
Dec 5, 2006·Expert Review of Anti-infective Therapy·Markus CornbergMichael P Manns
Mar 14, 2007·Scandinavian Journal of Gastroenterology·Melanie DeutschAthanasios J Archimandritis
Apr 21, 2007·Endocrinology·Antonino GrassadoniaUNKNOWN Consorzio Interuniversitario Nazionale per la Bioncologia
Jul 13, 2007·The New England Journal of Medicine·Mitchell L ShiffmanUNKNOWN ACCELERATE Investigators
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Henry L Y ChanUNKNOWN Interferon beta-1a Hepatitis C Study Group
Aug 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marcello PersicoAchille Iolascon
Aug 3, 2007·Journal of Gastroenterology·Tetsuro SuzukiTakaji Wakita
Sep 11, 2007·World Journal of Gastroenterology : WJG·Nasser Semmo, Paul Klenerman
Sep 11, 2007·World Journal of Gastroenterology : WJG·Eva BillerbeckRobert Thimme
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan J FeldMichael W Fried

❮ Previous
Next ❯

Citations

Mar 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Zoe RaglowYu-Jui Y Wan
Sep 28, 2015·Journal of Neonatal-perinatal Medicine·C ChanJ Kim
Feb 27, 2010·European Journal of Gastroenterology & Hepatology·Kin Jip CheungHans Van Vlierberghe
May 31, 2011·European Journal of Gastroenterology & Hepatology·Kin Jip CheungHans Van Vlierberghe
Sep 2, 2011·Pharmacological Reviews·Vanesa Gabriela MartínezFrancisco Lozano
May 10, 2016·World Journal of Gastroenterology : WJG·Tomohiro MaekawaEiji Miyoshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved